Functional imaging of cerebral oxygenation with intrinsic optical contrast and phosphorescent probes

Anna Devor, Sava Sakadžić, Mohammad A. Yaseen, Emmanuel Roussakis, Peifang Tian, Hamutal Slovin, Ivo Vanzetta, Ivan Teng, Payam A. Saisan, Louise E. Sinks, Anders M. Dale, Sergei A. Vinogradov, David A. Boas

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Microscopic in vivo measurements of cerebral oxygenation are of key importance for understanding normal cerebral energy metabolism and its dysregulation in a wide range of clinical conditions. Relevant cerebral pathologies include compromised blood perfusion following stroke and a decrease in efficiency of single-cell respiratory processes that occurs in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. In this chapter we review a number of quantitative optical approaches to measuring oxygenation of blood and cerebral tissue. These methods can be applied to map the hemodynamic response and study neurovascular and neurometabolic coupling, and can provide microscopic imaging of biomarkers in animal models of human disease, which would be useful for screening potential therapeutic approaches.

Original languageEnglish
Title of host publicationOptical Imaging of Neocortical Dynamics
Number of pages29
StatePublished - 2014

Publication series



  • CCD
  • Energy metabolism
  • Hemoglobin
  • In vivo imaging
  • Intrinsic optical signals
  • Phosphorescence quenching
  • Two-photon microscopy

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry,Genetics and Molecular Biology
  • General Neuroscience


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