@article{2597158c5d6b4acfbaed34676fa956e0,
title = "Functional classification of memory CD8 + T cells by CX 3 CR1 expression",
abstract = "Localization of memory CD8+ T cells to lymphoid or peripheral tissues is believed to correlate with proliferative capacity or effector function. Here we demonstrate that the fractalkine-receptor/CX 3 CR1 distinguishes memory CD8+ T cells with cytotoxic effector function from those with proliferative capacity, independent of tissue-homing properties. CX3 CR1-based transcriptome and proteome-profiling defines a core signature of memory CD8+ T cells with effector function. We find CD62L hi CX3 CR1+ memory T cells that reside within lymph nodes. This population shows distinct migration patterns and positioning in proximity to pathogen entry sites. Virus-specific CX3CR1+ memory CD8+ T cells are scarce during chronic infection in humans and mice but increase when infection is controlled spontaneously or by therapeutic intervention. This CX3 CR1-based functional classification will help to resolve the principles of protective CD8+ T-cell memory. 2015 Macmillan Publishers Limited. All rights reserved.",
author = "Boettcher, {Jan P.} and Marc Beyer and Felix Meissner and Zeinab Abdullah and Jil Sander and Bastian Hochst and Sarah Eickhoff and Rieckmann, {Jan C.} and Caroline Russo and Tanja Bauer and Tobias Flecken and Dominik Giesen and Daniel Engel and Steffen Jung and Busch, {Dirk H.} and Ulrike Protzer and Robert Thimme and Matthias Mann and Christian Kurts and Schultze, {Joachim L.} and Wolfgang Kastenmuller and Knolle, {Percy A.}",
note = "We thank Elmar Endl and Andreas Dolf from the core facility flow cytometry and cell sorting for excellent technical assistance and the DFG SFB 704, SFB TR36 and SFB TR57 and the Excellence Cluster ImmunoSensation for their support. We thank Caetano Reis e Sousa, Immunobiology Laboratory, Francis Crick Institute, for critical reading of the manuscript. Contributions J.P.B., M.B., F.M., Z.A., B.H., S.E., J.C.R., C.R., T.B., T.F., D.G., D.E. performed the experiments and analysed the data; M.B., F.M., J.C.R., J.S. and J.L.S. performed the bioinformatic analyses; F.M. and J.C.R. performed and analysed the proteomics measurements; J.P.B., M.B., F.M., S.J., D.H.B., U.P., R.T., M.M., C.K., J.L.S., W.K. and P.K. designed the experiments and provided essential reagents as well as essential analysis technology; J.P.B., M.B., F.M., J.L.S., C.K., W.K. and P.A.K. wrote the manuscript.",
year = "2015",
month = sep,
doi = "https://doi.org/10.1038/ncomms9306",
language = "الإنجليزيّة",
volume = "6",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
}