Functional characterization of the p53 "mutome"

Eran Kotler; Eran Segal; Moshe Oren

doi:https://doi.org/10.1080/23723556.2018.1511207

Functional characterization of the p53 "mutome"

Eran Kotler, Eran Segal, Moshe Oren

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

Phenotypic characterization of mutations in the tumor protein p53 (TP53) gene has so far focused on a handful of relatively frequent "hotspot" mutations, accounting for only similar to 30% of cases. We expanded the scope and quantitatively measured the impact of thousands of distinct TP53 mutations in vitro and in vivo, providing insights into the connections between structure, function, evolutionary conservation and clinical impact.

Original language	English
Article number	1511207
Number of pages	3
Journal	Molecular & cellular oncology
Volume	5
Issue number	6
DOIs	https://doi.org/10.1080/23723556.2018.1511207
State	Published Online - 25 Sep 2018

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title = "Functional characterization of the p53 {"}mutome{"}",

abstract = "Phenotypic characterization of mutations in the tumor protein p53 (TP53) gene has so far focused on a handful of relatively frequent {"}hotspot{"} mutations, accounting for only similar to 30% of cases. We expanded the scope and quantitatively measured the impact of thousands of distinct TP53 mutations in vitro and in vivo, providing insights into the connections between structure, function, evolutionary conservation and clinical impact.",

author = "Eran Kotler and Eran Segal and Moshe Oren",

note = "This work was supported in part by the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation and a Center of Excellence grant from the Israel Science Foundation (to M. Oren) and the European Research Council (to E. Segal).",

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AU - Kotler, Eran

AU - Segal, Eran

AU - Oren, Moshe

N1 - This work was supported in part by the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation and a Center of Excellence grant from the Israel Science Foundation (to M. Oren) and the European Research Council (to E. Segal).

PY - 2018/9/25

Y1 - 2018/9/25

N2 - Phenotypic characterization of mutations in the tumor protein p53 (TP53) gene has so far focused on a handful of relatively frequent "hotspot" mutations, accounting for only similar to 30% of cases. We expanded the scope and quantitatively measured the impact of thousands of distinct TP53 mutations in vitro and in vivo, providing insights into the connections between structure, function, evolutionary conservation and clinical impact.

AB - Phenotypic characterization of mutations in the tumor protein p53 (TP53) gene has so far focused on a handful of relatively frequent "hotspot" mutations, accounting for only similar to 30% of cases. We expanded the scope and quantitatively measured the impact of thousands of distinct TP53 mutations in vitro and in vivo, providing insights into the connections between structure, function, evolutionary conservation and clinical impact.

U2 - https://doi.org/10.1080/23723556.2018.1511207

DO - https://doi.org/10.1080/23723556.2018.1511207

M3 - مقالة

SN - 2372-3556

VL - 5

JO - Molecular & cellular oncology

JF - Molecular & cellular oncology

IS - 6

M1 - 1511207

ER -

Functional characterization of the p53 "mutome"

Abstract

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