Abstract
Phenotypic characterization of mutations in the tumor protein p53 (TP53) gene has so far focused on a handful of relatively frequent "hotspot" mutations, accounting for only similar to 30% of cases. We expanded the scope and quantitatively measured the impact of thousands of distinct TP53 mutations in vitro and in vivo, providing insights into the connections between structure, function, evolutionary conservation and clinical impact.
Original language | English |
---|---|
Article number | 1511207 |
Number of pages | 3 |
Journal | Molecular & cellular oncology |
Volume | 5 |
Issue number | 6 |
DOIs | |
State | Published Online - 25 Sep 2018 |