From synapse to nucleus and back again-communication over distance within neurons

Mike Fainzilber, Vivian Budnik, Rosalind A. Segal, Michael R. Kreutz

Research output: Contribution to journalArticlepeer-review

Abstract

How do neurons integrate intracellular communication from synapse to nucleus and back? Here we briefly summarize aspects of this topic covered by a symposium at Neuroscience 2011. A rich repertoire of signaling mechanisms link both dendritic terminals and axon tips with neuronalsomaandnucleus, usingmotor-dependenttransportmachineriestotraversethelongintracellulardistancesalongneuronalprocesses. Activation mechanisms at terminals include localized translation of dendritic or axonal RNA, proteolytic cleavage of receptors or second messengers, and differential phosphorylation of signaling moieties. Signaling complexes may be transported in endosomes, or as nonendosomal complexes associated with importins and dynein. Anterograde transport of RNA granules from the soma to neuronal processes, coupled with retrograde transport of proteins translated locally at terminals or within processes, may fuel ongoingbidirectional communication between soma and synapse to modulate synaptic plasticity as well as neuronal growth and survival decisions.

Original languageEnglish
Pages (from-to)16045-16048
Number of pages4
JournalJournal of Neuroscience
Volume31
Issue number45
DOIs
StatePublished - 9 Nov 2011

All Science Journal Classification (ASJC) codes

  • General Neuroscience

Fingerprint

Dive into the research topics of 'From synapse to nucleus and back again-communication over distance within neurons'. Together they form a unique fingerprint.

Cite this