@article{a8fe8854971b4d9ba8b6f6f0092e38a0,
title = "From synapse to nucleus and back again-communication over distance within neurons",
abstract = "How do neurons integrate intracellular communication from synapse to nucleus and back? Here we briefly summarize aspects of this topic covered by a symposium at Neuroscience 2011. A rich repertoire of signaling mechanisms link both dendritic terminals and axon tips with neuronalsomaandnucleus, usingmotor-dependenttransportmachineriestotraversethelongintracellulardistancesalongneuronalprocesses. Activation mechanisms at terminals include localized translation of dendritic or axonal RNA, proteolytic cleavage of receptors or second messengers, and differential phosphorylation of signaling moieties. Signaling complexes may be transported in endosomes, or as nonendosomal complexes associated with importins and dynein. Anterograde transport of RNA granules from the soma to neuronal processes, coupled with retrograde transport of proteins translated locally at terminals or within processes, may fuel ongoingbidirectional communication between soma and synapse to modulate synaptic plasticity as well as neuronal growth and survival decisions.",
author = "Mike Fainzilber and Vivian Budnik and Segal, {Rosalind A.} and Kreutz, {Michael R.}",
note = "Israel Science Foundation; German-Israeli Foundation; Minerva Foundation; International Foundation for Research in Paraplegia; Christopher and Dana Reeve Foundation; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; NIH [R01 NS063228, R01 MH091662, R01 NS050674]; Center for Brain and Behavior Sciences Magdeburg; Deutsche Forschungsgemeinschaft; Bundesministerium fur Bildung und Forschung; DZNE Magdeburg; Deutsche-Israelische Projektkooperation; Leibniz Foundation (Pakt fur Forschung); Schram FoundationWe gratefully acknowledge grant support as follows: M.F.-from the Israel Science Foundation, the German-Israeli Foundation, the Minerva Foundation, the International Foundation for Research in Paraplegia, the Christopher and Dana Reeve Foundation, and the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; V.B.-NIH Grant R01 NS063228; R.A.S.-NIH Grants R01 MH091662 and R01 NS050674; M.R.K.-Center for Brain and Behavior Sciences Magdeburg, Deutsche Forschungsgemeinschaft, Bundesministerium fur Bildung und Forschung, DZNE Magdeburg, the Deutsche-Israelische Projektkooperation, Leibniz Foundation (Pakt fur Forschung), and Schram Foundation.",
year = "2011",
month = nov,
day = "9",
doi = "https://doi.org/10.1523/JNEUROSCI.4006-11.2011",
language = "الإنجليزيّة",
volume = "31",
pages = "16045--16048",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "45",
}