Four Streams Within the Prefrontal Cortex: Integrating Structural and Functional Connectivity

Merging functional evidence derived from studies of autism spectrum disorder and attention-deficit/hyperactivity disorder converges in four neural streams of the prefrontal cortex, hence suggesting a model of information processing through four streams: motor through Brodmann area (BA) 8, emotion through BA 9, memory through BA 10, and emotional-related sensory through BA 11. A growing body of functional data has been supporting this model of information processing. Nevertheless, the underlying structural connectivity was only recently unveiled by a population-based high-definition tractography study with data from 1,065 individuals. This update provides a brief overview of recent evidence supporting the anatomofunctional integration of the four streams of the prefrontal cortex and reviews the white matter fiber tracts subserving the four streams.