Abstract
Quorum-sensing (QS) is a cell density-dependent signaling pathway regulated by gene expression for intra- and interspecies communication. We have targeted QS activity in Pseudomonas aeruginosa, an opportunistic human pathogen that causes disease in immunocompromised patients, with a set of probes containing a variety of functional groups, including photoreactive (diazirine) and affinity (alkyne) moieties, that were synthesized using a four-component Ugi reaction (Ugi-4CR).
Original language | American English |
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Article number | 107257 |
Journal | Bioorganic Chemistry |
Volume | 146 |
DOIs | |
State | Published - 1 May 2024 |
Keywords
- Multicomponent reactions (MCRs)
- P. aeruginosa
- Quorum sensing
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Molecular Biology
- Biochemistry
- Organic Chemistry