Formation of hydrophilic nanochannels in the membrane of living cells by the ringlike stable protein-SP1

Arkady Khoutorsky; Arnon Heyman; Oded Shoseyov; Micha E. Spira

doi:10.1021/nl201368w

Formation of hydrophilic nanochannels in the membrane of living cells by the ringlike stable protein-SP1

Arkady Khoutorsky, Arnon Heyman, Oded Shoseyov, Micha E. Spira

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

The assembly of functional junction between nerve cells and electronic sensing pads is a critical problem in the construction of effective neuroelectronic hybrid systems. Here, we demonstrate for the first time that the ringlike Stable Protein 1 (Sp1) and its derivatives can be used to generate hydrophilic nanochannels in the plasma membrane of living cells. Since SP1-derivatives can be linked to both the plasma membrane, gold or silicon surfaces, they may serve to ohmically link between cells interior and electronic sensing devices.

Original language	English
Pages (from-to)	2901-2904
Number of pages	4
Journal	Nano Letters
Volume	11
Issue number	7
DOIs	https://doi.org/10.1021/nl201368w
State	Published - 13 Jul 2011

Keywords

SP1
lipid membrane
nanochannel
neuroelectronic interface
neurons

All Science Journal Classification (ASJC) codes

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

Access to Document

10.1021/nl201368w

Cite this

@article{b5222cf3f8034c82b08fb7ffb28066c7,

title = "Formation of hydrophilic nanochannels in the membrane of living cells by the ringlike stable protein-SP1",

abstract = "The assembly of functional junction between nerve cells and electronic sensing pads is a critical problem in the construction of effective neuroelectronic hybrid systems. Here, we demonstrate for the first time that the ringlike Stable Protein 1 (Sp1) and its derivatives can be used to generate hydrophilic nanochannels in the plasma membrane of living cells. Since SP1-derivatives can be linked to both the plasma membrane, gold or silicon surfaces, they may serve to ohmically link between cells interior and electronic sensing devices.",

keywords = "SP1, lipid membrane, nanochannel, neuroelectronic interface, neurons",

author = "Arkady Khoutorsky and Arnon Heyman and Oded Shoseyov and Spira, \{Micha E.\}",

year = "2011",

month = jul,

day = "13",

doi = "10.1021/nl201368w",

language = "الإنجليزيّة",

volume = "11",

pages = "2901--2904",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

number = "7",

}

TY - JOUR

T1 - Formation of hydrophilic nanochannels in the membrane of living cells by the ringlike stable protein-SP1

AU - Khoutorsky, Arkady

AU - Heyman, Arnon

AU - Shoseyov, Oded

AU - Spira, Micha E.

PY - 2011/7/13

Y1 - 2011/7/13

N2 - The assembly of functional junction between nerve cells and electronic sensing pads is a critical problem in the construction of effective neuroelectronic hybrid systems. Here, we demonstrate for the first time that the ringlike Stable Protein 1 (Sp1) and its derivatives can be used to generate hydrophilic nanochannels in the plasma membrane of living cells. Since SP1-derivatives can be linked to both the plasma membrane, gold or silicon surfaces, they may serve to ohmically link between cells interior and electronic sensing devices.

AB - The assembly of functional junction between nerve cells and electronic sensing pads is a critical problem in the construction of effective neuroelectronic hybrid systems. Here, we demonstrate for the first time that the ringlike Stable Protein 1 (Sp1) and its derivatives can be used to generate hydrophilic nanochannels in the plasma membrane of living cells. Since SP1-derivatives can be linked to both the plasma membrane, gold or silicon surfaces, they may serve to ohmically link between cells interior and electronic sensing devices.

KW - SP1

KW - lipid membrane

KW - nanochannel

KW - neuroelectronic interface

KW - neurons

UR - http://www.scopus.com/inward/record.url?scp=79960262278&partnerID=8YFLogxK

U2 - 10.1021/nl201368w

DO - 10.1021/nl201368w

M3 - مقالة

C2 - 21651305

SN - 1530-6984

VL - 11

SP - 2901

EP - 2904

JO - Nano Letters

JF - Nano Letters

IS - 7

ER -

Formation of hydrophilic nanochannels in the membrane of living cells by the ringlike stable protein-SP1

Abstract

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this