Foot drop in patients treated with bortezomib–a case series and review of the literature

Iuliana Vaxman, Michelle L. Mauerman, Moshe L. Gatt, Tamar Berger, Morie A. Gertz

Research output: Contribution to journalArticlepeer-review


Bortezomib-induced peripheral neuropathy (BIPN) has a profound impact on quality of life, which is an important issue considering the growing number of survivors of multiple myeloma and amyloidosis. BIPN is typically symmetric, distal, "stocking and glove" distribution and predominantly consists of sensory rather than motor symptoms. In this case series, we report an acute neurotoxicity syndrome induced by bortezomib, which is clinically distinct from BIPN by not being peripheral and distal. We describe six patients that developed unilateral or bilateral foot drop attributed to bortezomib. With bortezomib discontinuation symptoms improved gradually over months to years.

Original languageEnglish
Pages (from-to)722-728
Number of pages7
JournalLeukemia and Lymphoma
Issue number3
StatePublished - 2022


  • Antineoplastic Agents/adverse effects
  • Bortezomib/adverse effects
  • Foot drop
  • Humans
  • Multiple Myeloma/complications
  • Peripheral Nervous System Diseases/chemically induced
  • Peroneal Neuropathies/chemically induced
  • Quality of Life
  • amyloidosis
  • bortezomib
  • multiple myeloma
  • neuropathy
  • peroneal nerve palsy

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research


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