Foot drop in patients treated with bortezomib–a case series and review of the literature

Iuliana Vaxman; Michelle L. Mauerman; Moshe L. Gatt; Tamar Berger; Morie A. Gertz

doi:https://doi.org/10.1080/10428194.2021.1992758

Foot drop in patients treated with bortezomib–a case series and review of the literature

Iuliana Vaxman, Michelle L. Mauerman, Moshe L. Gatt, Tamar Berger, Morie A. Gertz

Tel Aviv University, The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

Bortezomib-induced peripheral neuropathy (BIPN) has a profound impact on quality of life, which is an important issue considering the growing number of survivors of multiple myeloma and amyloidosis. BIPN is typically symmetric, distal, "stocking and glove" distribution and predominantly consists of sensory rather than motor symptoms. In this case series, we report an acute neurotoxicity syndrome induced by bortezomib, which is clinically distinct from BIPN by not being peripheral and distal. We describe six patients that developed unilateral or bilateral foot drop attributed to bortezomib. With bortezomib discontinuation symptoms improved gradually over months to years.

Original language	English
Pages (from-to)	722-728
Number of pages	7
Journal	Leukemia and Lymphoma
Volume	63
Issue number	3
DOIs	https://doi.org/10.1080/10428194.2021.1992758
State	Published - 2022

Keywords

Antineoplastic Agents/adverse effects
Bortezomib/adverse effects
Foot drop
Humans
Multiple Myeloma/complications
Peripheral Nervous System Diseases/chemically induced
Peroneal Neuropathies/chemically induced
Quality of Life
amyloidosis
bortezomib
multiple myeloma
neuropathy
peroneal nerve palsy

All Science Journal Classification (ASJC) codes

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.1080/10428194.2021.1992758

Cite this

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title = "Foot drop in patients treated with bortezomib–a case series and review of the literature",

abstract = "Bortezomib-induced peripheral neuropathy (BIPN) has a profound impact on quality of life, which is an important issue considering the growing number of survivors of multiple myeloma and amyloidosis. BIPN is typically symmetric, distal, {"}stocking and glove{"} distribution and predominantly consists of sensory rather than motor symptoms. In this case series, we report an acute neurotoxicity syndrome induced by bortezomib, which is clinically distinct from BIPN by not being peripheral and distal. We describe six patients that developed unilateral or bilateral foot drop attributed to bortezomib. With bortezomib discontinuation symptoms improved gradually over months to years.",

keywords = "Antineoplastic Agents/adverse effects, Bortezomib/adverse effects, Foot drop, Humans, Multiple Myeloma/complications, Peripheral Nervous System Diseases/chemically induced, Peroneal Neuropathies/chemically induced, Quality of Life, amyloidosis, bortezomib, multiple myeloma, neuropathy, peroneal nerve palsy",

author = "Iuliana Vaxman and Mauerman, {Michelle L.} and Gatt, {Moshe L.} and Tamar Berger and Gertz, {Morie A.}",

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year = "2022",

doi = "https://doi.org/10.1080/10428194.2021.1992758",

language = "الإنجليزيّة",

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TY - JOUR

T1 - Foot drop in patients treated with bortezomib–a case series and review of the literature

AU - Vaxman, Iuliana

AU - Mauerman, Michelle L.

AU - Gatt, Moshe L.

AU - Berger, Tamar

AU - Gertz, Morie A.

PY - 2022

Y1 - 2022

N2 - Bortezomib-induced peripheral neuropathy (BIPN) has a profound impact on quality of life, which is an important issue considering the growing number of survivors of multiple myeloma and amyloidosis. BIPN is typically symmetric, distal, "stocking and glove" distribution and predominantly consists of sensory rather than motor symptoms. In this case series, we report an acute neurotoxicity syndrome induced by bortezomib, which is clinically distinct from BIPN by not being peripheral and distal. We describe six patients that developed unilateral or bilateral foot drop attributed to bortezomib. With bortezomib discontinuation symptoms improved gradually over months to years.

AB - Bortezomib-induced peripheral neuropathy (BIPN) has a profound impact on quality of life, which is an important issue considering the growing number of survivors of multiple myeloma and amyloidosis. BIPN is typically symmetric, distal, "stocking and glove" distribution and predominantly consists of sensory rather than motor symptoms. In this case series, we report an acute neurotoxicity syndrome induced by bortezomib, which is clinically distinct from BIPN by not being peripheral and distal. We describe six patients that developed unilateral or bilateral foot drop attributed to bortezomib. With bortezomib discontinuation symptoms improved gradually over months to years.

KW - Antineoplastic Agents/adverse effects

KW - Bortezomib/adverse effects

KW - Foot drop

KW - Humans

KW - Multiple Myeloma/complications

KW - Peripheral Nervous System Diseases/chemically induced

KW - Peroneal Neuropathies/chemically induced

KW - Quality of Life

KW - amyloidosis

KW - bortezomib

KW - multiple myeloma

KW - neuropathy

KW - peroneal nerve palsy

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U2 - https://doi.org/10.1080/10428194.2021.1992758

DO - https://doi.org/10.1080/10428194.2021.1992758

M3 - مقالة

C2 - 34702127

SN - 1042-8194

VL - 63

SP - 722

EP - 728

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

IS - 3

ER -

Foot drop in patients treated with bortezomib–a case series and review of the literature

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

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