Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors

Ana Loureiro; Gonçalo J.L. Bernardes; Ulyana Shimanovich; Marisa P. Sárria; Eugénia Nogueira; Ana Preto; Andreia C. Gomes; Artur Cavaco-Paulo

doi:10.1016/j.nano.2015.02.022

Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors

Ana Loureiro, Gonçalo J.L. Bernardes, Ulyana Shimanovich, Marisa P. Sárria, Eugénia Nogueira, Ana Preto, Andreia C. Gomes, Artur Cavaco-Paulo

Research output: Contribution to journal › Article › peer-review

Abstract

Folic Acid (FA)-tagged protein nanoemulsions were found to be preferentially internalized on B-cell lymphoma cell line (A20 cell line), which, for the first time, is reported to express folate receptor (FR)-alpha. Carbon monoxide releasing molecule-2 (CORM-2) was incorporated in the oil phase of the initial formulation. FA-functionalized nanoemulsions loaded with CORM-2 exhibited a considerable antitumor effect and an increased survival of BALB/c mice bearing subcutaneous A20 lymphoma tumors. The developed nanoemulsions also demonstrated to be well tolerated by these immunocompetent mice. Thus, the results obtained in this study demonstrate that FA-tagged protein nanoemulsions can be successfully used in cancer therapy, with the important ability to delivery drugs intracellularly. From the Clinical Editor: In this research, the authors developed folic acid tagged nanoemulsions containing a carbon monoxide releasing protein molecule for targeted cancer cell treatment. In-vitro and in-vivo experiments showed efficacy against B-cell lymphoma cells. The same nanocarrier platform could be applied to other tumor cells expressing folate receptors on the cell surface.

Original language	English
Pages (from-to)	1077-1083
Number of pages	7
Journal	Nanomedicine: Nanotechnology, Biology, and Medicine
Volume	11
Issue number	5
DOIs	https://doi.org/10.1016/j.nano.2015.02.022
State	Published - 1 Jul 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CORM-2
Folic acid
Protein nanoemulsions
Specific uptake
Targeted drug delivery

All Science Journal Classification (ASJC) codes

Bioengineering
Medicine (miscellaneous)
Molecular Medicine
Biomedical Engineering
General Materials Science
Pharmaceutical Science

Access to Document

10.1016/j.nano.2015.02.022

http://hdl.handle.net/1822/35305License: Unspecified

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Loureiro, A., Bernardes, G. J. L., Shimanovich, U., Sárria, M. P., Nogueira, E., Preto, A., Gomes, A. C., & Cavaco-Paulo, A. (2015). Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors. Nanomedicine: Nanotechnology, Biology, and Medicine, 11(5), 1077-1083. https://doi.org/10.1016/j.nano.2015.02.022

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title = "Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors",

abstract = "Folic Acid (FA)-tagged protein nanoemulsions were found to be preferentially internalized on B-cell lymphoma cell line (A20 cell line), which, for the first time, is reported to express folate receptor (FR)-alpha. Carbon monoxide releasing molecule-2 (CORM-2) was incorporated in the oil phase of the initial formulation. FA-functionalized nanoemulsions loaded with CORM-2 exhibited a considerable antitumor effect and an increased survival of BALB/c mice bearing subcutaneous A20 lymphoma tumors. The developed nanoemulsions also demonstrated to be well tolerated by these immunocompetent mice. Thus, the results obtained in this study demonstrate that FA-tagged protein nanoemulsions can be successfully used in cancer therapy, with the important ability to delivery drugs intracellularly. From the Clinical Editor: In this research, the authors developed folic acid tagged nanoemulsions containing a carbon monoxide releasing protein molecule for targeted cancer cell treatment. In-vitro and in-vivo experiments showed efficacy against B-cell lymphoma cells. The same nanocarrier platform could be applied to other tumor cells expressing folate receptors on the cell surface.",

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Loureiro, A, Bernardes, GJL, Shimanovich, U, Sárria, MP, Nogueira, E, Preto, A, Gomes, AC & Cavaco-Paulo, A 2015, 'Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 11, no. 5, pp. 1077-1083. https://doi.org/10.1016/j.nano.2015.02.022

TY - JOUR

T1 - Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors

AU - Loureiro, Ana

AU - Bernardes, Gonçalo J.L.

AU - Shimanovich, Ulyana

AU - Sárria, Marisa P.

AU - Nogueira, Eugénia

AU - Preto, Ana

AU - Gomes, Andreia C.

AU - Cavaco-Paulo, Artur

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Folic Acid (FA)-tagged protein nanoemulsions were found to be preferentially internalized on B-cell lymphoma cell line (A20 cell line), which, for the first time, is reported to express folate receptor (FR)-alpha. Carbon monoxide releasing molecule-2 (CORM-2) was incorporated in the oil phase of the initial formulation. FA-functionalized nanoemulsions loaded with CORM-2 exhibited a considerable antitumor effect and an increased survival of BALB/c mice bearing subcutaneous A20 lymphoma tumors. The developed nanoemulsions also demonstrated to be well tolerated by these immunocompetent mice. Thus, the results obtained in this study demonstrate that FA-tagged protein nanoemulsions can be successfully used in cancer therapy, with the important ability to delivery drugs intracellularly. From the Clinical Editor: In this research, the authors developed folic acid tagged nanoemulsions containing a carbon monoxide releasing protein molecule for targeted cancer cell treatment. In-vitro and in-vivo experiments showed efficacy against B-cell lymphoma cells. The same nanocarrier platform could be applied to other tumor cells expressing folate receptors on the cell surface.

AB - Folic Acid (FA)-tagged protein nanoemulsions were found to be preferentially internalized on B-cell lymphoma cell line (A20 cell line), which, for the first time, is reported to express folate receptor (FR)-alpha. Carbon monoxide releasing molecule-2 (CORM-2) was incorporated in the oil phase of the initial formulation. FA-functionalized nanoemulsions loaded with CORM-2 exhibited a considerable antitumor effect and an increased survival of BALB/c mice bearing subcutaneous A20 lymphoma tumors. The developed nanoemulsions also demonstrated to be well tolerated by these immunocompetent mice. Thus, the results obtained in this study demonstrate that FA-tagged protein nanoemulsions can be successfully used in cancer therapy, with the important ability to delivery drugs intracellularly. From the Clinical Editor: In this research, the authors developed folic acid tagged nanoemulsions containing a carbon monoxide releasing protein molecule for targeted cancer cell treatment. In-vitro and in-vivo experiments showed efficacy against B-cell lymphoma cells. The same nanocarrier platform could be applied to other tumor cells expressing folate receptors on the cell surface.

KW - CORM-2

KW - Folic acid

KW - Protein nanoemulsions

KW - Specific uptake

KW - Targeted drug delivery

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M3 - مقالة

C2 - 25791804

SN - 1549-9634

VL - 11

SP - 1077

EP - 1083

JO - Nanomedicine: Nanotechnology, Biology, and Medicine

JF - Nanomedicine: Nanotechnology, Biology, and Medicine

IS - 5

ER -

Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors

Abstract

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

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