FMRI contrast at high and ultrahigh magnetic fields: Insight from complementary methods

Luisa Ciobanu, Eddy Solomon, Nadya Pyatigorskaya, Tangi Roussel, Denis Le Bihan, Lucio Frydman

Research output: Contribution to journalArticlepeer-review


This manuscript examines the origins and nature of the function-derived activation detected by magnetic resonance imaging at ultrahigh fields using different encoding methods. A series of preclinical high field (7. T) and ultra-high field (17.2. T) fMRI experiments were performed using gradient echo EPI, spin echo EPI and spatio-temporally encoded (SPEN) strategies. The dependencies of the fMRI signal change on the strength of the magnetic field and on different acquisition and sequence parameters were investigated. Artifact-free rat brain images with good resolution in all areas, as well as significant localized activation maps upon forepaw stimulation, were obtained in a single scan using fully refocused SPEN sequences devoid of T2* effects. Our results showed that, besides the normal T2-weighted BOLD contribution that arises in spin-echo sequences, fMRI SPEN signals contain a strong component caused by apparent T1-related effects, demonstrating the potential of such technique for exploring functional activation in rodents and on humans at ultrahigh fields.

Original languageEnglish
Pages (from-to)37-43
Number of pages7
StatePublished - 1 Jun 2015

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience


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