Fluorescent Calixarene Scaffolds for NO Detection in Protic Media

Brij Bhushan Ahuja, Arkadi Vigalok

Research output: Contribution to journalArticlepeer-review


We present the first fluorescent water-soluble conjugated calixarene scaffolds that are capable of NO gas detection. Two different scaffolds, one based on a 5,5′-bicalixarene structure and its isomer bearing two distantly conjugated calixarene moieties, were synthesized. While the fluorescence of both isomers is quenched upon either passing of NO gas or generating it in situ from diethylamine NONOate, the bicalixarene-based scaffold showed a significantly stronger response. We also present an example of a dye encapsulation strategy to achieve the detection of NO at longer wavelengths than in the parent calixarene host. Finally, a conjugated polymer bearing a 5,5′-bicalixarene scaffold has also been prepared and demonstrated enhanced sensitivity compared to the monomer due to the molecular wire effect.

Original languageEnglish
Pages (from-to)2774-2778
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number9
StatePublished - 25 Feb 2019


  • calixarenes
  • conjugated systems
  • fluorescent probes
  • host–guest chemistry
  • nitric oxide

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)


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