Fluorescent antitumor titanium(IV) salen complexes for cell imaging

Avia Tzubery; Naomi Melamed-Book; Edit Y. Tshuva

doi:10.1039/c7dt04828a

Fluorescent antitumor titanium(IV) salen complexes for cell imaging

Avia Tzubery, Naomi Melamed-Book, Edit Y. Tshuva

Institute of Chemistry

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

Two differently substituted fluorescent salen Ti(iv) complexes were developed. One was inactive on human cancer cells, whereas the other showed high cytotoxicity. Based on live cell imaging, both complexes penetrated the cell, but were not detected in the nuclei. Moreover, the inactive complex was trapped in endocytic vesicles, whereas the active complex accumulated in the perinuclear region and inflected phototoxicity upon continuous irradiation.

Original language	English
Pages (from-to)	3669-3673
Number of pages	5
Journal	Dalton Transactions
Volume	47
Issue number	11
DOIs	https://doi.org/10.1039/c7dt04828a
State	Published - 2018

All Science Journal Classification (ASJC) codes

Inorganic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c7dt04828a

Cite this

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title = "Fluorescent antitumor titanium(IV) salen complexes for cell imaging",

abstract = "Two differently substituted fluorescent salen Ti(iv) complexes were developed. One was inactive on human cancer cells, whereas the other showed high cytotoxicity. Based on live cell imaging, both complexes penetrated the cell, but were not detected in the nuclei. Moreover, the inactive complex was trapped in endocytic vesicles, whereas the active complex accumulated in the perinuclear region and inflected phototoxicity upon continuous irradiation.",

author = "Avia Tzubery and Naomi Melamed-Book and Tshuva, {Edit Y.}",

note = "Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",

year = "2018",

doi = "10.1039/c7dt04828a",

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AU - Tzubery, Avia

AU - Melamed-Book, Naomi

AU - Tshuva, Edit Y.

PY - 2018

Y1 - 2018

N2 - Two differently substituted fluorescent salen Ti(iv) complexes were developed. One was inactive on human cancer cells, whereas the other showed high cytotoxicity. Based on live cell imaging, both complexes penetrated the cell, but were not detected in the nuclei. Moreover, the inactive complex was trapped in endocytic vesicles, whereas the active complex accumulated in the perinuclear region and inflected phototoxicity upon continuous irradiation.

AB - Two differently substituted fluorescent salen Ti(iv) complexes were developed. One was inactive on human cancer cells, whereas the other showed high cytotoxicity. Based on live cell imaging, both complexes penetrated the cell, but were not detected in the nuclei. Moreover, the inactive complex was trapped in endocytic vesicles, whereas the active complex accumulated in the perinuclear region and inflected phototoxicity upon continuous irradiation.

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U2 - 10.1039/c7dt04828a

DO - 10.1039/c7dt04828a

M3 - مقالة

C2 - 29451281

SN - 1477-9226

VL - 47

SP - 3669

EP - 3673

JO - Dalton Transactions

JF - Dalton Transactions

IS - 11

ER -

Fluorescent antitumor titanium(IV) salen complexes for cell imaging

Abstract

All Science Journal Classification (ASJC) codes

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