Flow models for efficient simulation and engineering of transcription and translation elongation

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Gene expression is a fundamental cellular process by which proteins are synthesized based on the information coded in the genes. Understanding, modeling and engineering this process have both important biotechnological applications and contributions to basic life science. In this paper I describe the flow models- a new approach for computationally modeling the biophysics of gene expression. The flow models can describe various stages of gene expression in a computationally efficient manner; in addition, they can be more readily analyzed mathematically than alternative models. Thus, these models provide a comprehensive framework for in-silico engineering of gene expression.

Original languageEnglish
Title of host publication2012 IEEE 27th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2012
DOIs
StatePublished - 2012
Event2012 IEEE 27th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2012 - Eilat, Israel
Duration: 14 Nov 201217 Nov 2012

Publication series

Name2012 IEEE 27th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2012

Conference

Conference2012 IEEE 27th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2012
Country/TerritoryIsrael
CityEilat
Period14/11/1217/11/12

Keywords

  • Gene expression
  • biomedical engineering
  • computational modeling
  • flow models
  • gene expression engineering
  • modeling of intra-cellular processes
  • transcription
  • translation

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

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