Fixation and absorption in a fluctuating environment

Matan Danino, Nadav M. Shnerb

Research output: Contribution to journalArticlepeer-review

Abstract

A fundamental problem in the fields of population genetics, evolution, and community ecology, is the fate of a single mutant, or invader, introduced in a finite population of wild types. For a fixed-size community of N individuals, with Markovian, zero-sum dynamics driven by stochastic birth-death events, the mutant population eventually reaches either fixation or extinction. The classical analysis, provided by Kimura and his coworkers, is focused on the neutral case, [where the dynamics is only due to demographic stochasticity (drift)], and on time-independent selective forces (deleterious/beneficial mutation). However, both theoretical arguments and empirical analyses suggest that in many cases the selective forces fluctuate in time (temporal environmental stochasticity). Here we consider a generic model for a system with demographic noise and fluctuating selection. Our system is characterized by the time-averaged (log)-fitness s 0 and zero-mean fitness fluctuations. These fluctuations, in turn, are parameterized by their amplitude γ and their correlation time δ. We provide asymptotic (large N) formulas for the chance of fixation, the mean time to fixation and the mean time to absorption. Our expressions interpolate correctly between the constant selection limit γ → 0 and the time-averaged neutral case s 0 =0.

Original languageEnglish
Pages (from-to)84-92
Number of pages9
JournalJournal of Theoretical Biology
Volume441
DOIs
StatePublished - 14 Mar 2018

Keywords

  • Absorption
  • Demographic stochasticity
  • Drift
  • Environmental stochasticity
  • Evolution
  • Fixation
  • Selection

All Science Journal Classification (ASJC) codes

  • General Immunology and Microbiology
  • Applied Mathematics
  • General Biochemistry,Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • Statistics and Probability
  • Modelling and Simulation

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