First-in-Human Study of Bone Pathologies Using Low-Cost and Compact Dual-Wavelength Photoacoustic System

Idan Steinberg, Lihi Shiloh, Israel Gannot, Avishay Eyal

Research output: Contribution to journalArticlepeer-review


Osteoporosis affects one-third of the elderly population worldwide with associated health care costs amounting to tens of billions of dollars annually. Identifying and treating the population at risk of fracture, but had not yet suffered from a fracture, can substantially reduce fracture incidence. Unfortunately, molecular changes in the bone, which are of great importance for early diagnosis, are not detected by current low-cost diagnostic methods. To address this issue, presented here is a clinically translatable, dual-modality multispectral photoacoustic system. Ex vivo experiments demonstrated sensitivity to the molecular changes. Specifically, the system enabled a quantitative measurement of the marrow’s blood/fat ratio. First-in-human demonstration on healthy human volunteers showed the repeatability and accuracy of the photoacoustic method and its potential for early diagnosis of bone pathologies.

Original languageEnglish
Article number7201908
JournalIEEE Journal of Selected Topics in Quantum Electronics
Issue number1
StatePublished - 2018


  • Photoacoustic imaging
  • diode lasers
  • medical instruments
  • ultrasonography

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering


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