Fear generalization in the primate amygdala

Jennifer Resnik; Rony Paz

doi:10.1038/nn.3900

Fear generalization in the primate amygdala

Jennifer Resnik, Rony Paz

Department of Brain Sciences

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

Broad generalization of negative memories is a potential etiology for anxiety disorders, yet the underlying mechanisms remain unknown. We developed a non-human primate model that replicates behavioral observations in humans and identifies specific changes in tuning properties of amygdala neurons: the width of auditory tuning increases with the distance of its center from the conditioned stimulus. This center-width relationship can account for better detection and at the same time explain the wide stimulus generalization.

Original language	American English
Pages (from-to)	188-190
Number of pages	3
Journal	Nature Neuroscience
Volume	18
Issue number	2
DOIs	https://doi.org/10.1038/nn.3900
State	Published - 17 Feb 2015

All Science Journal Classification (ASJC) codes

General Neuroscience

Access to Document

10.1038/nn.3900

Cite this

@article{c621e5d0ec6e4953a4ff470e6eaeb9d7,

title = "Fear generalization in the primate amygdala",

abstract = "Broad generalization of negative memories is a potential etiology for anxiety disorders, yet the underlying mechanisms remain unknown. We developed a non-human primate model that replicates behavioral observations in humans and identifies specific changes in tuning properties of amygdala neurons: the width of auditory tuning increases with the distance of its center from the conditioned stimulus. This center-width relationship can account for better detection and at the same time explain the wide stimulus generalization.",

author = "Jennifer Resnik and Rony Paz",

note = "Funding Information: We are grateful to H. Sompolinsky for discussions and suggestions. We thank Y. Shohat for major contribution to the work and welfare of the animals, E. Kahana and G. Hecht for help with medical and surgical procedures, E. Furman-Haran and N. Stern for magnetic resonance imaging procedures. This work was supported by the Minerva Foundation and the Israel Science Foundation (\#26613 and ERC-FP7-StG \#281171, R.P.).",

year = "2015",

month = feb,

day = "17",

doi = "10.1038/nn.3900",

language = "American English",

volume = "18",

pages = "188--190",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature Research",

number = "2",

}

TY - JOUR

T1 - Fear generalization in the primate amygdala

AU - Resnik, Jennifer

AU - Paz, Rony

N1 - Funding Information: We are grateful to H. Sompolinsky for discussions and suggestions. We thank Y. Shohat for major contribution to the work and welfare of the animals, E. Kahana and G. Hecht for help with medical and surgical procedures, E. Furman-Haran and N. Stern for magnetic resonance imaging procedures. This work was supported by the Minerva Foundation and the Israel Science Foundation (#26613 and ERC-FP7-StG #281171, R.P.).

PY - 2015/2/17

Y1 - 2015/2/17

N2 - Broad generalization of negative memories is a potential etiology for anxiety disorders, yet the underlying mechanisms remain unknown. We developed a non-human primate model that replicates behavioral observations in humans and identifies specific changes in tuning properties of amygdala neurons: the width of auditory tuning increases with the distance of its center from the conditioned stimulus. This center-width relationship can account for better detection and at the same time explain the wide stimulus generalization.

AB - Broad generalization of negative memories is a potential etiology for anxiety disorders, yet the underlying mechanisms remain unknown. We developed a non-human primate model that replicates behavioral observations in humans and identifies specific changes in tuning properties of amygdala neurons: the width of auditory tuning increases with the distance of its center from the conditioned stimulus. This center-width relationship can account for better detection and at the same time explain the wide stimulus generalization.

UR - http://www.scopus.com/inward/record.url?scp=84923209893&partnerID=8YFLogxK

U2 - 10.1038/nn.3900

DO - 10.1038/nn.3900

M3 - Article

C2 - 25531573

SN - 1097-6256

VL - 18

SP - 188

EP - 190

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 2

ER -

Fear generalization in the primate amygdala

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this