Fast T1 mapping MRI in preclinical and clinical settings using subspace-constrained joint-domain reconstructions

Lingceng Ma, Qingjia Bao, Ricardo P. Martinho, Zhong Chen, Lucio Frydman

Research output: Contribution to journalArticlepeer-review

Abstract

This work aims to develop fast T1 mapping methods for preclinical and clinical scanners based on subspace-constrained reconstructions. Two sequences are explored for rapid T1 characterizations: 1) Interleaved spatiotemporal encoding incorporating variable repetition times. 2) Inversion recovery gradient echo with random sampling of the phase-encoding (PE) dimension. For both sequences, the subspace reconstruction of the signal recovery was applied, to jointly reconstruct the down-sampled images while characterizing the T1 relaxation. In vivo scans on human brains and abdomens confirmed the efficiency of the proposed methods, including compatibility with breath-holding. In addition, Scans on animals with abdominal tumors and dynamic contrast-enhanced T1 mapping on kidneys support the applicability of the proposed methods also in preclinical settings.

Original languageEnglish
Article number200134
JournalMagnetic Resonance Letters
DOIs
StatePublished Online - 27 Apr 2024

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Fingerprint

Dive into the research topics of 'Fast T1 mapping MRI in preclinical and clinical settings using subspace-constrained joint-domain reconstructions'. Together they form a unique fingerprint.

Cite this