Farnesol and Candida albicans: Quorum Sensing or Not Quorum Sensing?

Bastiaan P. Krom, Niva Levy, Michael M. Meijler, Mary Ann Jabra-Rizk

Research output: Contribution to journalReview articlepeer-review


Quorum sensing (QS) molecules function within communities of single-cell organisms to allow concerted behavior in response to changing conditions, and certain criteria have been established to determine whether a particular molecule is quorum sensing or not. Farnesol has been identified as a secreted molecule responsible for the inoculum size effect in Candida albicans and synthetic farnesol has been used as a QS molecule in different studies. However, farnesol also exhibits growth inhibitory effects, and so a critical evaluation of farnesol is warranted. Here we review the literature to determine whether or not farnesol can indeed be considered a QS molecule in C. albicans.

Original languageAmerican English
Pages (from-to)295-301
Number of pages7
JournalIsrael Journal of Chemistry
Issue number5
StatePublished - 1 May 2016


  • Candida albicans
  • apoptosis
  • farnesol
  • metabolism
  • quorum sensing

All Science Journal Classification (ASJC) codes

  • General Chemistry


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