Abstract
Proline-rich tyrosine kinase 2 (PYK2, also known as Pyk2) and its closely related focal adhesion kinase (FAK) modulate cancer cell invasion by coordinating the balance between focal adhesion-mediated migration and invadopodia-dependent extracellular matrix invasion. Our recent findings present Pyk2 and FAK as novel mediators of breast cancer invasiveness and as potential targets for blocking breast cancer metastasis.
| Original language | English |
|---|---|
| Article number | e1449584 |
| Journal | Molecular and Cellular Oncology |
| Volume | 5 |
| Issue number | 4 |
| DOIs | |
| State | Published - 4 Jul 2018 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- FAK
- Pyk2
- focal adhesions
- invadopodia
- invasion
- migration
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Cancer Research
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