Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs

Boris Redko; Amnon Albeck; Gary Gellerman

doi:10.1039/c2nj40567a

Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs

Boris Redko, Amnon Albeck, Gary Gellerman

Ariel University, Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Abstract

A facile synthesis of novel antitumor N(9)-methyl-3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives is described. Boc protection of aminobenzoic acids followed by LiAlH₄ reduction yielded novel methylaminobenzyl alcohol reactants. Their interaction with 9-chloroacridine provides N(9)-methylated AHMA derivatives for biological screening. A preliminary anti-proliferative assay against seven cancer cell lines identified compounds with low μM IC₅₀ values.

Original language	English
Pages (from-to)	2188-2191
Number of pages	4
Journal	New Journal of Chemistry
Volume	36
Issue number	11
DOIs	https://doi.org/10.1039/c2nj40567a
State	Published - Nov 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry
Materials Chemistry

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10.1039/c2nj40567a

Cite this

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abstract = "A facile synthesis of novel antitumor N(9)-methyl-3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives is described. Boc protection of aminobenzoic acids followed by LiAlH4 reduction yielded novel methylaminobenzyl alcohol reactants. Their interaction with 9-chloroacridine provides N(9)-methylated AHMA derivatives for biological screening. A preliminary anti-proliferative assay against seven cancer cell lines identified compounds with low μM IC50 values.",

author = "Boris Redko and Amnon Albeck and Gary Gellerman",

year = "2012",

month = nov,

doi = "10.1039/c2nj40567a",

language = "الإنجليزيّة",

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journal = "New Journal of Chemistry",

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AU - Redko, Boris

AU - Albeck, Amnon

AU - Gellerman, Gary

PY - 2012/11

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N2 - A facile synthesis of novel antitumor N(9)-methyl-3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives is described. Boc protection of aminobenzoic acids followed by LiAlH4 reduction yielded novel methylaminobenzyl alcohol reactants. Their interaction with 9-chloroacridine provides N(9)-methylated AHMA derivatives for biological screening. A preliminary anti-proliferative assay against seven cancer cell lines identified compounds with low μM IC50 values.

AB - A facile synthesis of novel antitumor N(9)-methyl-3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives is described. Boc protection of aminobenzoic acids followed by LiAlH4 reduction yielded novel methylaminobenzyl alcohol reactants. Their interaction with 9-chloroacridine provides N(9)-methylated AHMA derivatives for biological screening. A preliminary anti-proliferative assay against seven cancer cell lines identified compounds with low μM IC50 values.

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U2 - 10.1039/c2nj40567a

DO - 10.1039/c2nj40567a

M3 - مقالة

SN - 1144-0546

VL - 36

SP - 2188

EP - 2191

JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 11

ER -

Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs

Abstract

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