Exposure to omega-3 fatty acids at early age accelerate bone growth and improve bone quality

Netta Koren, Stav Simsa-Maziel, Ron Shahar, Betty Schwartz, Efrat Monsonego-Ornan

Research output: Contribution to journalArticlepeer-review


Omega-3 fatty acids (FAs) are essential nutritional components that must be obtained from foods. Increasing evidence validate that omega-3 FAs are beneficial for bone health, and several mechanisms have been suggested to mediate their effects on bone, including alterations in calcium absorption and urinary calcium loss, prostaglandin synthesis, lipid oxidation, osteoblast formation and inhibition of osteoclastogenesis. However, to date, there is scant information regarding the effect of omega-3 FAs on the developing skeleton during the rapid growth phase. In this study we aim to evaluate the effect of exposure to high levels of omega-3 FAs on bone development and quality during prenatal and early postnatal period. For this purpose, we used the fat-1 transgenic mice that have the ability to convert omega-6 to omega-3 fatty acids and the ATDC5 chondrogenic cell line as models. We show that exposure to high concentrations of omega-3 FAs at a young age accelerates bone growth through alterations of the growth plate, associated with increased chondrocyte proliferation and differentiation. We further propose that those effects are mediated by the receptors G-protein coupled receptor 120 (GPR120) and hepatic nuclear factor 4α, which are expressed by chondrocytes in culture. Additionally, using a combined study on the structural and mechanical bone parameters, we show that high omega-3 levels contribute to superior trabecular and cortical structure, as well as to stiffer bones and improved bone quality. Most interestingly, the fat-1 model allowed us to demonstrate the role of maternal high omega-3 concentration on bone growth during the gestation and postnatal period.

Original languageAmerican English
Pages (from-to)623-633
Number of pages11
JournalJournal of Nutritional Biochemistry
Issue number6
StatePublished - Jun 2014


  • Bone mechanics
  • Bone structure
  • Chondrocyte differentiation
  • Growth plate
  • ω-3 Desaturase
  • ω-3 Fatty acids

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Nutrition and Dietetics
  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism


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