Exploiting fluorescein based drug conjugates for fluorescent monitoring in drug delivery

Andrii Bazylevich; Leonid D. Patsenker; Gary Gellerman

doi:10.1016/j.dyepig.2016.11.057

Exploiting fluorescein based drug conjugates for fluorescent monitoring in drug delivery

Andrii Bazylevich, Leonid D. Patsenker, Gary Gellerman

Ariel University

Research output: Contribution to journal › Article › peer-review

Abstract

Anticancer drugs connected to fluorescein based chemosensors by different biodegradable linkers were investigated for fluorescent monitoring in drug delivery models. The drug release triggered by chemo- and bio-hydrolytic environments was visualized on the basis of “switch on” fluorescence of the fluorophore moiety of fluorescein-drug conjugates. The conjugation of free phenolic hydroxyl of fluorescein chemosensor to the hydroxyl group of the drugs was employed by biodegradable oxy- and amino acrylate linkers. The chemosensor also possesses a free carboxylic group for potential conjugation to a specific carrier for targeted drug delivery applications. Fluorescent monitoring of drug release, quantum yield and other spectroscopic characteristics of our novel fluorescein-drug conjugates were measured and discussed. The work offers a versatile fluorophore platform for the fluorescent observation of drug delivery.

Original language	English
Pages (from-to)	460-472
Number of pages	13
Journal	Dyes and Pigments
Volume	139
DOIs	https://doi.org/10.1016/j.dyepig.2016.11.057
State	Published - 1 Apr 2017

Keywords

Anticancer
Chemosensing
Drug conjugates
Drug delivery monitoring
Fluorescein
Fluorescence
TDD

All Science Journal Classification (ASJC) codes

General Chemical Engineering
Process Chemistry and Technology

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10.1016/j.dyepig.2016.11.057

Cite this

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title = "Exploiting fluorescein based drug conjugates for fluorescent monitoring in drug delivery",

abstract = "Anticancer drugs connected to fluorescein based chemosensors by different biodegradable linkers were investigated for fluorescent monitoring in drug delivery models. The drug release triggered by chemo- and bio-hydrolytic environments was visualized on the basis of “switch on” fluorescence of the fluorophore moiety of fluorescein-drug conjugates. The conjugation of free phenolic hydroxyl of fluorescein chemosensor to the hydroxyl group of the drugs was employed by biodegradable oxy- and amino acrylate linkers. The chemosensor also possesses a free carboxylic group for potential conjugation to a specific carrier for targeted drug delivery applications. Fluorescent monitoring of drug release, quantum yield and other spectroscopic characteristics of our novel fluorescein-drug conjugates were measured and discussed. The work offers a versatile fluorophore platform for the fluorescent observation of drug delivery.",

keywords = "Anticancer, Chemosensing, Drug conjugates, Drug delivery monitoring, Fluorescein, Fluorescence, TDD",

author = "Andrii Bazylevich and Patsenker, {Leonid D.} and Gary Gellerman",

note = "Publisher Copyright: {\textcopyright} 2016",

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doi = "10.1016/j.dyepig.2016.11.057",

language = "الإنجليزيّة",

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TY - JOUR

T1 - Exploiting fluorescein based drug conjugates for fluorescent monitoring in drug delivery

AU - Bazylevich, Andrii

AU - Patsenker, Leonid D.

AU - Gellerman, Gary

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Anticancer drugs connected to fluorescein based chemosensors by different biodegradable linkers were investigated for fluorescent monitoring in drug delivery models. The drug release triggered by chemo- and bio-hydrolytic environments was visualized on the basis of “switch on” fluorescence of the fluorophore moiety of fluorescein-drug conjugates. The conjugation of free phenolic hydroxyl of fluorescein chemosensor to the hydroxyl group of the drugs was employed by biodegradable oxy- and amino acrylate linkers. The chemosensor also possesses a free carboxylic group for potential conjugation to a specific carrier for targeted drug delivery applications. Fluorescent monitoring of drug release, quantum yield and other spectroscopic characteristics of our novel fluorescein-drug conjugates were measured and discussed. The work offers a versatile fluorophore platform for the fluorescent observation of drug delivery.

AB - Anticancer drugs connected to fluorescein based chemosensors by different biodegradable linkers were investigated for fluorescent monitoring in drug delivery models. The drug release triggered by chemo- and bio-hydrolytic environments was visualized on the basis of “switch on” fluorescence of the fluorophore moiety of fluorescein-drug conjugates. The conjugation of free phenolic hydroxyl of fluorescein chemosensor to the hydroxyl group of the drugs was employed by biodegradable oxy- and amino acrylate linkers. The chemosensor also possesses a free carboxylic group for potential conjugation to a specific carrier for targeted drug delivery applications. Fluorescent monitoring of drug release, quantum yield and other spectroscopic characteristics of our novel fluorescein-drug conjugates were measured and discussed. The work offers a versatile fluorophore platform for the fluorescent observation of drug delivery.

KW - Anticancer

KW - Chemosensing

KW - Drug conjugates

KW - Drug delivery monitoring

KW - Fluorescein

KW - Fluorescence

KW - TDD

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U2 - 10.1016/j.dyepig.2016.11.057

DO - 10.1016/j.dyepig.2016.11.057

M3 - مقالة

SN - 0143-7208

VL - 139

SP - 460

EP - 472

JO - Dyes and Pigments

JF - Dyes and Pigments

ER -

Exploiting fluorescein based drug conjugates for fluorescent monitoring in drug delivery

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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