Experience-dependent plasticity of mature adult-born neurons

Yoav Livneh; Adi Mizrahi

doi:https://doi.org/10.1038/nn.2980

Experience-dependent plasticity of mature adult-born neurons

Yoav Livneh, Adi Mizrahi

Department of Neurobiology (Natural Sciences)

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

The adult olfactory bulb and hippocampus are continuously supplied with newborn neurons that are thought to possess a capacity for plasticity only at a young neuronal age, mainly during the early stages of integration into the network. We find that the two main types of adult-born neurons in the mouse olfactory bulb undergo experience-dependent plasticity long after maturation and integration, as evidenced by stabilization of synaptic turnover rates. Thus, the potential time window for plasticity of adult-born neurons extends well into maturity.

Original language	English
Pages (from-to)	26-28
Number of pages	3
Journal	Nature Neuroscience
Volume	15
Issue number	1
Early online date	13 Nov 2011
DOIs	https://doi.org/10.1038/nn.2980
State	Published - Jan 2012

All Science Journal Classification (ASJC) codes

General Neuroscience

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https://doi.org/10.1038/nn.2980

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title = "Experience-dependent plasticity of mature adult-born neurons",

abstract = "The adult olfactory bulb and hippocampus are continuously supplied with newborn neurons that are thought to possess a capacity for plasticity only at a young neuronal age, mainly during the early stages of integration into the network. We find that the two main types of adult-born neurons in the mouse olfactory bulb undergo experience-dependent plasticity long after maturation and integration, as evidenced by stabilization of synaptic turnover rates. Thus, the potential time window for plasticity of adult-born neurons extends well into maturity.",

author = "Yoav Livneh and Adi Mizrahi",

note = "Funding Information: We thank H. Spors (Max Planck Institute of Biophysics, Frankfurt, Germany) for the analysis software for the intrinsic signals. We thank Y. Adam for assistance with surgical procedures. We thank members of the Mizrahi laboratory and D. Nachmani for discussions and for commenting on the manuscript. This work was supported by European Research Council (203994) and ERA-NET (0398216) grants to A.M. Y.L. is supported by the Adams Fellowship Program of the Israel Academy of Sciences and Humanities.",

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Experience-dependent plasticity of mature adult-born neurons

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