Expanding the boundaries of embryonic stem cells

Uri Ben-David; Oded Kopper; Nissim Benvenisty

doi:10.1016/j.stem.2012.05.003

Expanding the boundaries of embryonic stem cells

Department of Genetics

The Hebrew University of Jerusalem

Research output: Contribution to journal › Review article › peer-review

Abstract

The boundaries of embryonic stem cell (ESC) research have extended considerably in recent years in several important ways. Alongside a deeper understanding of the pluripotent state, ESCs have been successfully integrated into various fields, such as genomics, epigenetics, and disease modeling. Significant progress in cell fate control has pushed directed differentiation and tissue engineering further than ever before and promoted clinical trials. The geographical distribution of research activity has also expanded, especially for human ESCs. This review outlines these developments and future challenges that remain.

Original language	English
Pages (from-to)	666-677
Number of pages	12
Journal	Cell Stem Cell
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/j.stem.2012.05.003
State	Published - 14 Jun 2012

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2012.05.003

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title = "Expanding the boundaries of embryonic stem cells",

abstract = "The boundaries of embryonic stem cell (ESC) research have extended considerably in recent years in several important ways. Alongside a deeper understanding of the pluripotent state, ESCs have been successfully integrated into various fields, such as genomics, epigenetics, and disease modeling. Significant progress in cell fate control has pushed directed differentiation and tissue engineering further than ever before and promoted clinical trials. The geographical distribution of research activity has also expanded, especially for human ESCs. This review outlines these developments and future challenges that remain.",

author = "Uri Ben-David and Oded Kopper and Nissim Benvenisty",

note = "Funding Information: The authors thank Dr. Daniel Ronen for critically reading this manuscript and Tamar Golan-Lev for her assistance with the graphical design of the figures. N.B. is the Herbert Cohn Chair in Cancer Research. This research was partially supported by the Legacy Heritage Biomedical Science Partnership Program of the Israel Science Foundation (grant 943/09), the Centers of Excellence Legacy Heritage Biomedical Science Partnership (grant 1801/10), and the Juvenile Diabetes Research Foundation (grant 1-2011-555).",

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doi = "10.1016/j.stem.2012.05.003",

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AU - Ben-David, Uri

AU - Kopper, Oded

AU - Benvenisty, Nissim

N1 - Funding Information: The authors thank Dr. Daniel Ronen for critically reading this manuscript and Tamar Golan-Lev for her assistance with the graphical design of the figures. N.B. is the Herbert Cohn Chair in Cancer Research. This research was partially supported by the Legacy Heritage Biomedical Science Partnership Program of the Israel Science Foundation (grant 943/09), the Centers of Excellence Legacy Heritage Biomedical Science Partnership (grant 1801/10), and the Juvenile Diabetes Research Foundation (grant 1-2011-555).

PY - 2012/6/14

Y1 - 2012/6/14

N2 - The boundaries of embryonic stem cell (ESC) research have extended considerably in recent years in several important ways. Alongside a deeper understanding of the pluripotent state, ESCs have been successfully integrated into various fields, such as genomics, epigenetics, and disease modeling. Significant progress in cell fate control has pushed directed differentiation and tissue engineering further than ever before and promoted clinical trials. The geographical distribution of research activity has also expanded, especially for human ESCs. This review outlines these developments and future challenges that remain.

AB - The boundaries of embryonic stem cell (ESC) research have extended considerably in recent years in several important ways. Alongside a deeper understanding of the pluripotent state, ESCs have been successfully integrated into various fields, such as genomics, epigenetics, and disease modeling. Significant progress in cell fate control has pushed directed differentiation and tissue engineering further than ever before and promoted clinical trials. The geographical distribution of research activity has also expanded, especially for human ESCs. This review outlines these developments and future challenges that remain.

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DO - 10.1016/j.stem.2012.05.003

M3 - Review article

C2 - 22704506

SN - 1934-5909

VL - 10

SP - 666

EP - 677

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 6

ER -

Expanding the boundaries of embryonic stem cells

Abstract

ASJC Scopus subject areas

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