Excitatory deep transcranial magnetic stimulation with H-coil over the right homologous Broca's region improves naming in chronic post-stroke aphasia

Raffaella Chieffo; Federico Ferrari; Petronilla Battista; Elise Houdayer; Arturo Nuara; Federica Alemanno; Jubin Abutalebi; Abraham Zangen; Giancarlo Comi; Stefano F. Cappa; Letizia Leocani

doi:https://doi.org/10.1177/1545968313508471

Excitatory deep transcranial magnetic stimulation with H-coil over the right homologous Broca's region improves naming in chronic post-stroke aphasia

Raffaella Chieffo, Federico Ferrari, Petronilla Battista, Elise Houdayer, Arturo Nuara, Federica Alemanno, Jubin Abutalebi, Abraham Zangen, Giancarlo Comi, Stefano F. Cappa, Letizia Leocani

Department of Life Sciences

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

Background. The role of the right hemisphere in poststroke aphasia recovery is still controversial and the effects of repetitive transcranial magnetic stimulation (rTMS) over the right homologous Broca's region have been seldom investigated. Objective. This study aimed to compare the effect of excitatory, inhibitory, and sham rTMS delivered with H-coil over the right inferior frontal gyrus in chronic aphasic patients. Methods. Five right-handed poststroke aphasic patients underwent a picture naming task before and immediately after each of 3 sessions of rTMS: excitatory (10 Hz), inhibitory (1 Hz), and sham rTMS, in random sequence and separated by at least 1 week. Results. Only the excitatory 10-Hz stimulation was associated with a significant improvement in naming performance (P =.043) and was significantly more effective than 1-Hz rTMS (P =.043). Conclusions. A single session of excitatory deep brain rTMS over the right inferior frontal gyrus with H-coil significantly improves naming in right-handed chronic poststroke aphasic patients. This result is in line with the hypothesis of a positive, rather than detrimental, role of the right hemisphere in chronic aphasia due to a left-hemispheric stroke.

Original language	American English
Pages (from-to)	291-298
Number of pages	8
Journal	Neurorehabilitation and Neural Repair
Volume	28
Issue number	3
DOIs	https://doi.org/10.1177/1545968313508471
State	Published - 1 Mar 2014

Keywords

H-coil
aphasia
rTMS
stroke rehabilitation
transcranial magnetic stimulation

All Science Journal Classification (ASJC) codes

Clinical Neurology
Neurology
Rehabilitation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.1177/1545968313508471

Cite this

Chieffo, R., Ferrari, F., Battista, P., Houdayer, E., Nuara, A., Alemanno, F., Abutalebi, J., Zangen, A., Comi, G., Cappa, S. F., & Leocani, L. (2014). Excitatory deep transcranial magnetic stimulation with H-coil over the right homologous Broca's region improves naming in chronic post-stroke aphasia. Neurorehabilitation and Neural Repair, 28(3), 291-298. https://doi.org/10.1177/1545968313508471

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title = "Excitatory deep transcranial magnetic stimulation with H-coil over the right homologous Broca's region improves naming in chronic post-stroke aphasia",

abstract = "Background. The role of the right hemisphere in poststroke aphasia recovery is still controversial and the effects of repetitive transcranial magnetic stimulation (rTMS) over the right homologous Broca's region have been seldom investigated. Objective. This study aimed to compare the effect of excitatory, inhibitory, and sham rTMS delivered with H-coil over the right inferior frontal gyrus in chronic aphasic patients. Methods. Five right-handed poststroke aphasic patients underwent a picture naming task before and immediately after each of 3 sessions of rTMS: excitatory (10 Hz), inhibitory (1 Hz), and sham rTMS, in random sequence and separated by at least 1 week. Results. Only the excitatory 10-Hz stimulation was associated with a significant improvement in naming performance (P =.043) and was significantly more effective than 1-Hz rTMS (P =.043). Conclusions. A single session of excitatory deep brain rTMS over the right inferior frontal gyrus with H-coil significantly improves naming in right-handed chronic poststroke aphasic patients. This result is in line with the hypothesis of a positive, rather than detrimental, role of the right hemisphere in chronic aphasia due to a left-hemispheric stroke.",

keywords = "H-coil, aphasia, rTMS, stroke rehabilitation, transcranial magnetic stimulation",

author = "Raffaella Chieffo and Federico Ferrari and Petronilla Battista and Elise Houdayer and Arturo Nuara and Federica Alemanno and Jubin Abutalebi and Abraham Zangen and Giancarlo Comi and Cappa, {Stefano F.} and Letizia Leocani",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Joint Italian-Israeli Laboratory San Raffaele-Weizmann (Italian Ministry of Foreign Affairs).",

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doi = "https://doi.org/10.1177/1545968313508471",

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Chieffo, R, Ferrari, F, Battista, P, Houdayer, E, Nuara, A, Alemanno, F, Abutalebi, J, Zangen, A, Comi, G, Cappa, SF & Leocani, L 2014, 'Excitatory deep transcranial magnetic stimulation with H-coil over the right homologous Broca's region improves naming in chronic post-stroke aphasia', Neurorehabilitation and Neural Repair, vol. 28, no. 3, pp. 291-298. https://doi.org/10.1177/1545968313508471

Excitatory deep transcranial magnetic stimulation with H-coil over the right homologous Broca's region improves naming in chronic post-stroke aphasia. / Chieffo, Raffaella; Ferrari, Federico; Battista, Petronilla et al.
In: Neurorehabilitation and Neural Repair, Vol. 28, No. 3, 01.03.2014, p. 291-298.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Excitatory deep transcranial magnetic stimulation with H-coil over the right homologous Broca's region improves naming in chronic post-stroke aphasia

AU - Chieffo, Raffaella

AU - Ferrari, Federico

AU - Battista, Petronilla

AU - Houdayer, Elise

AU - Nuara, Arturo

AU - Alemanno, Federica

AU - Abutalebi, Jubin

AU - Zangen, Abraham

AU - Comi, Giancarlo

AU - Cappa, Stefano F.

AU - Leocani, Letizia

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Joint Italian-Israeli Laboratory San Raffaele-Weizmann (Italian Ministry of Foreign Affairs).

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Background. The role of the right hemisphere in poststroke aphasia recovery is still controversial and the effects of repetitive transcranial magnetic stimulation (rTMS) over the right homologous Broca's region have been seldom investigated. Objective. This study aimed to compare the effect of excitatory, inhibitory, and sham rTMS delivered with H-coil over the right inferior frontal gyrus in chronic aphasic patients. Methods. Five right-handed poststroke aphasic patients underwent a picture naming task before and immediately after each of 3 sessions of rTMS: excitatory (10 Hz), inhibitory (1 Hz), and sham rTMS, in random sequence and separated by at least 1 week. Results. Only the excitatory 10-Hz stimulation was associated with a significant improvement in naming performance (P =.043) and was significantly more effective than 1-Hz rTMS (P =.043). Conclusions. A single session of excitatory deep brain rTMS over the right inferior frontal gyrus with H-coil significantly improves naming in right-handed chronic poststroke aphasic patients. This result is in line with the hypothesis of a positive, rather than detrimental, role of the right hemisphere in chronic aphasia due to a left-hemispheric stroke.

AB - Background. The role of the right hemisphere in poststroke aphasia recovery is still controversial and the effects of repetitive transcranial magnetic stimulation (rTMS) over the right homologous Broca's region have been seldom investigated. Objective. This study aimed to compare the effect of excitatory, inhibitory, and sham rTMS delivered with H-coil over the right inferior frontal gyrus in chronic aphasic patients. Methods. Five right-handed poststroke aphasic patients underwent a picture naming task before and immediately after each of 3 sessions of rTMS: excitatory (10 Hz), inhibitory (1 Hz), and sham rTMS, in random sequence and separated by at least 1 week. Results. Only the excitatory 10-Hz stimulation was associated with a significant improvement in naming performance (P =.043) and was significantly more effective than 1-Hz rTMS (P =.043). Conclusions. A single session of excitatory deep brain rTMS over the right inferior frontal gyrus with H-coil significantly improves naming in right-handed chronic poststroke aphasic patients. This result is in line with the hypothesis of a positive, rather than detrimental, role of the right hemisphere in chronic aphasia due to a left-hemispheric stroke.

KW - H-coil

KW - aphasia

KW - rTMS

KW - stroke rehabilitation

KW - transcranial magnetic stimulation

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U2 - https://doi.org/10.1177/1545968313508471

DO - https://doi.org/10.1177/1545968313508471

M3 - Article

C2 - 24243918

SN - 1545-9683

VL - 28

SP - 291

EP - 298

JO - Neurorehabilitation and Neural Repair

JF - Neurorehabilitation and Neural Repair

IS - 3

ER -

Excitatory deep transcranial magnetic stimulation with H-coil over the right homologous Broca's region improves naming in chronic post-stroke aphasia

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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