Evaluation the effect of acute hyperglycemia on cerebral tissue properties with diffuse optical imaging systems

David Abookasis; David Shemesh; Naor Bokobza; Hadas Bloygrund; Yarden Franjy-Tal; Konstantin Rozenberg; Tovit Rosenzweig

doi:https://doi.org/10.1117/12.2551867

Evaluation the effect of acute hyperglycemia on cerebral tissue properties with diffuse optical imaging systems

David Abookasis, David Shemesh, Naor Bokobza, Hadas Bloygrund, Yarden Franjy-Tal, Konstantin Rozenberg, Tovit Rosenzweig

Ariel University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In this work, we demonstrate the application of two optical imaging systems namely, dual-wavelength laser speckle and integrated spatial frequency domain imaging systems to image the changes in mouse brain tissue properties following acute hyperglycemia. We assume that hyperglycemia alters brain function which in turn can be monitored using these two optical modalities. Hyperglycemia was induced by intraperitoneal injection of an anesthetic ketamine and xylazine combination which is found to increase blood glucose more than threefold relative to normoglycemia. A total of ten mice were used, randomized into two groups of normoglycemia (n = 4) and hyperglycemia (n = 6). Experimental results demonstrated reductions in cerebral blood flow, tissue oxygen saturation, and cerebral metabolic rate of oxygen following acute hyperglycemia. In addition, differences in both cerebral tissue optical properties (absorption and scattering) with increasing glucose level were observed. Overall, experimental result demonstrates the capability of both systems to provide and map various brain tissue metrics following hyperglycemia.

Original language	English
Title of host publication	Neurophotonics
Editors	Francesco Saverio Pavone, Laurent Cognet, Thomas Kuner
Publisher	SPIE
ISBN (Electronic)	9781510634923
DOIs	https://doi.org/10.1117/12.2551867
State	Published - 1 Jan 2020
Event	Neurophotonics 2020 - none, France Duration: 6 Apr 2020 → 10 Apr 2020

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	11360

Conference

Conference	Neurophotonics 2020
Country/Territory	France
City	none
Period	6/04/20 → 10/04/20

Keywords

Cerebral hemodynamics and metabolism
Hyperglycemia
Laser speckle imaging
Optical properties
Structured illumination

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Access to Document

https://doi.org/10.1117/12.2551867

Cite this

Abookasis, D., Shemesh, D., Bokobza, N., Bloygrund, H., Franjy-Tal, Y., Rozenberg, K., & Rosenzweig, T. (2020). Evaluation the effect of acute hyperglycemia on cerebral tissue properties with diffuse optical imaging systems. In F. S. Pavone, L. Cognet, & T. Kuner (Eds.), Neurophotonics Article 113600F (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11360). SPIE. https://doi.org/10.1117/12.2551867

@inproceedings{5b4313c0d3f64467995e972a1cc71b16,

title = "Evaluation the effect of acute hyperglycemia on cerebral tissue properties with diffuse optical imaging systems",

abstract = "In this work, we demonstrate the application of two optical imaging systems namely, dual-wavelength laser speckle and integrated spatial frequency domain imaging systems to image the changes in mouse brain tissue properties following acute hyperglycemia. We assume that hyperglycemia alters brain function which in turn can be monitored using these two optical modalities. Hyperglycemia was induced by intraperitoneal injection of an anesthetic ketamine and xylazine combination which is found to increase blood glucose more than threefold relative to normoglycemia. A total of ten mice were used, randomized into two groups of normoglycemia (n = 4) and hyperglycemia (n = 6). Experimental results demonstrated reductions in cerebral blood flow, tissue oxygen saturation, and cerebral metabolic rate of oxygen following acute hyperglycemia. In addition, differences in both cerebral tissue optical properties (absorption and scattering) with increasing glucose level were observed. Overall, experimental result demonstrates the capability of both systems to provide and map various brain tissue metrics following hyperglycemia.",

keywords = "Cerebral hemodynamics and metabolism, Hyperglycemia, Laser speckle imaging, Optical properties, Structured illumination",

author = "David Abookasis and David Shemesh and Naor Bokobza and Hadas Bloygrund and Yarden Franjy-Tal and Konstantin Rozenberg and Tovit Rosenzweig",

note = "Publisher Copyright: {\textcopyright} 2020 SPIE.; Neurophotonics 2020 ; Conference date: 06-04-2020 Through 10-04-2020",

year = "2020",

month = jan,

day = "1",

doi = "https://doi.org/10.1117/12.2551867",

language = "الإنجليزيّة",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

publisher = "SPIE",

editor = "Pavone, {Francesco Saverio} and Laurent Cognet and Thomas Kuner",

booktitle = "Neurophotonics",

address = "الولايات المتّحدة",

}

Abookasis, D, Shemesh, D, Bokobza, N, Bloygrund, H, Franjy-Tal, Y, Rozenberg, K & Rosenzweig, T 2020, Evaluation the effect of acute hyperglycemia on cerebral tissue properties with diffuse optical imaging systems. in FS Pavone, L Cognet & T Kuner (eds), Neurophotonics., 113600F, Proceedings of SPIE - The International Society for Optical Engineering, vol. 11360, SPIE, Neurophotonics 2020, none, France, 6/04/20. https://doi.org/10.1117/12.2551867

Evaluation the effect of acute hyperglycemia on cerebral tissue properties with diffuse optical imaging systems. / Abookasis, David; Shemesh, David; Bokobza, Naor et al.
Neurophotonics. ed. / Francesco Saverio Pavone; Laurent Cognet; Thomas Kuner. SPIE, 2020. 113600F (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11360).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Evaluation the effect of acute hyperglycemia on cerebral tissue properties with diffuse optical imaging systems

AU - Abookasis, David

AU - Shemesh, David

AU - Bokobza, Naor

AU - Bloygrund, Hadas

AU - Franjy-Tal, Yarden

AU - Rozenberg, Konstantin

AU - Rosenzweig, Tovit

PY - 2020/1/1

Y1 - 2020/1/1

N2 - In this work, we demonstrate the application of two optical imaging systems namely, dual-wavelength laser speckle and integrated spatial frequency domain imaging systems to image the changes in mouse brain tissue properties following acute hyperglycemia. We assume that hyperglycemia alters brain function which in turn can be monitored using these two optical modalities. Hyperglycemia was induced by intraperitoneal injection of an anesthetic ketamine and xylazine combination which is found to increase blood glucose more than threefold relative to normoglycemia. A total of ten mice were used, randomized into two groups of normoglycemia (n = 4) and hyperglycemia (n = 6). Experimental results demonstrated reductions in cerebral blood flow, tissue oxygen saturation, and cerebral metabolic rate of oxygen following acute hyperglycemia. In addition, differences in both cerebral tissue optical properties (absorption and scattering) with increasing glucose level were observed. Overall, experimental result demonstrates the capability of both systems to provide and map various brain tissue metrics following hyperglycemia.

AB - In this work, we demonstrate the application of two optical imaging systems namely, dual-wavelength laser speckle and integrated spatial frequency domain imaging systems to image the changes in mouse brain tissue properties following acute hyperglycemia. We assume that hyperglycemia alters brain function which in turn can be monitored using these two optical modalities. Hyperglycemia was induced by intraperitoneal injection of an anesthetic ketamine and xylazine combination which is found to increase blood glucose more than threefold relative to normoglycemia. A total of ten mice were used, randomized into two groups of normoglycemia (n = 4) and hyperglycemia (n = 6). Experimental results demonstrated reductions in cerebral blood flow, tissue oxygen saturation, and cerebral metabolic rate of oxygen following acute hyperglycemia. In addition, differences in both cerebral tissue optical properties (absorption and scattering) with increasing glucose level were observed. Overall, experimental result demonstrates the capability of both systems to provide and map various brain tissue metrics following hyperglycemia.

KW - Cerebral hemodynamics and metabolism

KW - Hyperglycemia

KW - Laser speckle imaging

KW - Optical properties

KW - Structured illumination

UR - http://www.scopus.com/inward/record.url?scp=85084190703&partnerID=8YFLogxK

U2 - https://doi.org/10.1117/12.2551867

DO - https://doi.org/10.1117/12.2551867

M3 - منشور من مؤتمر

T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Neurophotonics

A2 - Pavone, Francesco Saverio

A2 - Cognet, Laurent

A2 - Kuner, Thomas

PB - SPIE

T2 - Neurophotonics 2020

Y2 - 6 April 2020 through 10 April 2020

ER -

Abookasis D, Shemesh D, Bokobza N, Bloygrund H, Franjy-Tal Y, Rozenberg K et al. Evaluation the effect of acute hyperglycemia on cerebral tissue properties with diffuse optical imaging systems. In Pavone FS, Cognet L, Kuner T, editors, Neurophotonics. SPIE. 2020. 113600F. (Proceedings of SPIE - The International Society for Optical Engineering). doi: https://doi.org/10.1117/12.2551867

Evaluation the effect of acute hyperglycemia on cerebral tissue properties with diffuse optical imaging systems

Abstract

Publication series

Conference

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this