Etrog Citron (Citrus medica) as a Novel Source of Antimicrobial Agents: Overview of Its Bioactive Phytochemicals and Delivery Approaches

Arik Dahan; Ludmila Yarmolinsky; Faina Nakonechny; Olga Semenova; Boris Khalfin; Shimon Ben-Shabat

doi:10.3390/pharmaceutics17060761

Etrog Citron (Citrus medica) as a Novel Source of Antimicrobial Agents: Overview of Its Bioactive Phytochemicals and Delivery Approaches

Arik Dahan, Ludmila Yarmolinsky, Faina Nakonechny, Olga Semenova, Boris Khalfin, Shimon Ben-Shabat

Ben-Gurion University of the Negev, Ariel University

Research output: Contribution to journal › Review article › peer-review

Abstract

The rising prevalence of bacterial antibiotic resistance remains a significant challenge, while many existing antibacterial agents exhibit limited efficacy and notable adverse effects. Edible plants offer a promising avenue for developing novel antimicrobial drugs and preservatives. Etrog citron (Citrus medica L.) and its bioactive phytochemicals have demonstrated activity against various pathogenic microorganisms. However, the potential application of these compounds is hindered by factors such as poor solubility, limited bioavailability, and unclear mechanisms of action. This review consolidates key findings on the antimicrobial properties of extracts and essential oils derived from different parts of Citrus medica, emphasizing strategies for improving the delivery of these bioactive compounds.

Original language	English
Article number	761
Journal	Pharmaceutics
Volume	17
Issue number	6
DOIs	https://doi.org/10.3390/pharmaceutics17060761
State	Published - Jun 2025

Keywords

antibacterial properties
Citrus medica
coumarins
Etrog citron
flavonoids
terpenes

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

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10.3390/pharmaceutics17060761

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abstract = "The rising prevalence of bacterial antibiotic resistance remains a significant challenge, while many existing antibacterial agents exhibit limited efficacy and notable adverse effects. Edible plants offer a promising avenue for developing novel antimicrobial drugs and preservatives. Etrog citron (Citrus medica L.) and its bioactive phytochemicals have demonstrated activity against various pathogenic microorganisms. However, the potential application of these compounds is hindered by factors such as poor solubility, limited bioavailability, and unclear mechanisms of action. This review consolidates key findings on the antimicrobial properties of extracts and essential oils derived from different parts of Citrus medica, emphasizing strategies for improving the delivery of these bioactive compounds.",

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AU - Dahan, Arik

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AU - Semenova, Olga

AU - Khalfin, Boris

AU - Ben-Shabat, Shimon

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AB - The rising prevalence of bacterial antibiotic resistance remains a significant challenge, while many existing antibacterial agents exhibit limited efficacy and notable adverse effects. Edible plants offer a promising avenue for developing novel antimicrobial drugs and preservatives. Etrog citron (Citrus medica L.) and its bioactive phytochemicals have demonstrated activity against various pathogenic microorganisms. However, the potential application of these compounds is hindered by factors such as poor solubility, limited bioavailability, and unclear mechanisms of action. This review consolidates key findings on the antimicrobial properties of extracts and essential oils derived from different parts of Citrus medica, emphasizing strategies for improving the delivery of these bioactive compounds.

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KW - Citrus medica

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Etrog Citron (Citrus medica) as a Novel Source of Antimicrobial Agents: Overview of Its Bioactive Phytochemicals and Delivery Approaches

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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