Escherichia coli dysbiosis correlates with gastrointestinal dysfunction in children with cystic fibrosis

Lucas R. Hoffman; Christopher E. Pope; Hillary S. Hayden; Sonya Heltshe; Roie Levy; Sharon McNamara; Michael A. Jacobs; Laurence Rohmer; Matthew Radey; Bonnie W. Ramsey; Mitchell J. Brittnacher; Elhanan Borenstein; Samuel I. Miller

doi:10.1093/cid/cit715

Escherichia coli dysbiosis correlates with gastrointestinal dysfunction in children with cystic fibrosis

Lucas R. Hoffman
, Christopher E. Pope
, Hillary S. Hayden
, Sonya Heltshe
, Roie Levy
, Sharon McNamara
, Michael A. Jacobs
, Laurence Rohmer
, Matthew Radey
, Bonnie W. Ramsey
, Mitchell J. Brittnacher
, Elhanan Borenstein
, Samuel I. Miller

Research output: Contribution to journal › Article › peer-review

Abstract

Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal inflammation. We show that the abundances of Escherichia coli in fecal microbiota were significantly higher in young children with cystic fibrosis than in controls and correlated with fecal measures of nutrient malabsorption and inflammation, suggesting that E. coli could contribute to cystic fibrosis gastrointestinal dysfunction.

Original language	English
Pages (from-to)	396-399
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	58
Issue number	3
DOIs	https://doi.org/10.1093/cid/cit715
State	Published - Feb 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Escherichia coli
cystic fibrosis
inflammation
malabsorption
microbiota

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

Access to Document

10.1093/cid/cit715

Cite this

Hoffman, L. R., Pope, C. E., Hayden, H. S., Heltshe, S., Levy, R., McNamara, S., Jacobs, M. A., Rohmer, L., Radey, M., Ramsey, B. W., Brittnacher, M. J., Borenstein, E., & Miller, S. I. (2014). Escherichia coli dysbiosis correlates with gastrointestinal dysfunction in children with cystic fibrosis. Clinical Infectious Diseases, 58(3), 396-399. https://doi.org/10.1093/cid/cit715

@article{48b1c28f33e04c2288ee21afd61dbf8a,

title = "Escherichia coli dysbiosis correlates with gastrointestinal dysfunction in children with cystic fibrosis",

abstract = "Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal inflammation. We show that the abundances of Escherichia coli in fecal microbiota were significantly higher in young children with cystic fibrosis than in controls and correlated with fecal measures of nutrient malabsorption and inflammation, suggesting that E. coli could contribute to cystic fibrosis gastrointestinal dysfunction.",

keywords = "Escherichia coli, cystic fibrosis, inflammation, malabsorption, microbiota",

author = "Hoffman, \{Lucas R.\} and Pope, \{Christopher E.\} and Hayden, \{Hillary S.\} and Sonya Heltshe and Roie Levy and Sharon McNamara and Jacobs, \{Michael A.\} and Laurence Rohmer and Matthew Radey and Ramsey, \{Bonnie W.\} and Brittnacher, \{Mitchell J.\} and Elhanan Borenstein and Miller, \{Samuel I.\}",

note = "Funding Information: Financial support. This work was supported by the National Institutes of Health (grant numbers P30 DK089507 and K02 HL105543). Potential conflicts of interest. All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.",

year = "2014",

month = feb,

doi = "10.1093/cid/cit715",

language = "الإنجليزيّة",

volume = "58",

pages = "396--399",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

number = "3",

}

TY - JOUR

T1 - Escherichia coli dysbiosis correlates with gastrointestinal dysfunction in children with cystic fibrosis

AU - Hoffman, Lucas R.

AU - Pope, Christopher E.

AU - Hayden, Hillary S.

AU - Heltshe, Sonya

AU - Levy, Roie

AU - McNamara, Sharon

AU - Jacobs, Michael A.

AU - Rohmer, Laurence

AU - Radey, Matthew

AU - Ramsey, Bonnie W.

AU - Brittnacher, Mitchell J.

AU - Borenstein, Elhanan

AU - Miller, Samuel I.

N1 - Funding Information: Financial support. This work was supported by the National Institutes of Health (grant numbers P30 DK089507 and K02 HL105543). Potential conflicts of interest. All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

PY - 2014/2

Y1 - 2014/2

N2 - Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal inflammation. We show that the abundances of Escherichia coli in fecal microbiota were significantly higher in young children with cystic fibrosis than in controls and correlated with fecal measures of nutrient malabsorption and inflammation, suggesting that E. coli could contribute to cystic fibrosis gastrointestinal dysfunction.

AB - Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal inflammation. We show that the abundances of Escherichia coli in fecal microbiota were significantly higher in young children with cystic fibrosis than in controls and correlated with fecal measures of nutrient malabsorption and inflammation, suggesting that E. coli could contribute to cystic fibrosis gastrointestinal dysfunction.

KW - Escherichia coli

KW - cystic fibrosis

KW - inflammation

KW - malabsorption

KW - microbiota

UR - https://www.scopus.com/pages/publications/84892769426

U2 - 10.1093/cid/cit715

DO - 10.1093/cid/cit715

M3 - مقالة

SN - 1058-4838

VL - 58

SP - 396

EP - 399

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 3

ER -

Escherichia coli dysbiosis correlates with gastrointestinal dysfunction in children with cystic fibrosis

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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