EsBAF safeguards Stat3 binding to maintain pluripotency

Noa Novershtern; Jacob H. Hanna

doi:10.1038/ncb2311

EsBAF safeguards Stat3 binding to maintain pluripotency

Noa Novershtern, Jacob H. Hanna

Department of Molecular Genetics

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

How the unique chromatin configuration of embryonic stem cells (ESCs) integrates inputs from exogenous stimuli to maintain pluripotency remains largely unknown. The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Stat3, a leukaemia inhibitory factor (LIF) signalling effector, by preventing repressive localized polycomb-mediated trimethylation of Lys 27 of histone 3 (H3K27me3).

Original language	English
Pages (from-to)	886-888
Number of pages	3
Journal	Nature Cell Biology
Volume	13
Issue number	8
DOIs	https://doi.org/10.1038/ncb2311
State	Published - Aug 2011

All Science Journal Classification (ASJC) codes

Cell Biology

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10.1038/ncb2311

Cite this

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title = "EsBAF safeguards Stat3 binding to maintain pluripotency",

abstract = "How the unique chromatin configuration of embryonic stem cells (ESCs) integrates inputs from exogenous stimuli to maintain pluripotency remains largely unknown. The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Stat3, a leukaemia inhibitory factor (LIF) signalling effector, by preventing repressive localized polycomb-mediated trimethylation of Lys 27 of histone 3 (H3K27me3).",

author = "Noa Novershtern and Hanna, {Jacob H.}",

year = "2011",

month = aug,

doi = "10.1038/ncb2311",

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journal = "Nature Cell Biology",

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AB - How the unique chromatin configuration of embryonic stem cells (ESCs) integrates inputs from exogenous stimuli to maintain pluripotency remains largely unknown. The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Stat3, a leukaemia inhibitory factor (LIF) signalling effector, by preventing repressive localized polycomb-mediated trimethylation of Lys 27 of histone 3 (H3K27me3).

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U2 - 10.1038/ncb2311

DO - 10.1038/ncb2311

M3 - مقالة

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SP - 886

EP - 888

JO - Nature Cell Biology

JF - Nature Cell Biology

IS - 8

ER -

EsBAF safeguards Stat3 binding to maintain pluripotency

Abstract

All Science Journal Classification (ASJC) codes

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