EsBAF safeguards Stat3 binding to maintain pluripotency

Noa Novershtern; Jacob H. Hanna

doi:10.1038/ncb2311

EsBAF safeguards Stat3 binding to maintain pluripotency

Noa Novershtern
, Jacob H. Hanna

Department of Molecular Genetics

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

How the unique chromatin configuration of embryonic stem cells (ESCs) integrates inputs from exogenous stimuli to maintain pluripotency remains largely unknown. The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Stat3, a leukaemia inhibitory factor (LIF) signalling effector, by preventing repressive localized polycomb-mediated trimethylation of Lys 27 of histone 3 (H3K27me3).

Original language	English GB
Pages (from-to)	886-888
Number of pages	3
Journal	Nature Cell Biology
Volume	13
Issue number	8
DOIs	https://doi.org/10.1038/ncb2311
State	Published - Aug 2011

ASJC Scopus subject areas

Cell Biology

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title = "EsBAF safeguards Stat3 binding to maintain pluripotency",

abstract = "How the unique chromatin configuration of embryonic stem cells (ESCs) integrates inputs from exogenous stimuli to maintain pluripotency remains largely unknown. The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Stat3, a leukaemia inhibitory factor (LIF) signalling effector, by preventing repressive localized polycomb-mediated trimethylation of Lys 27 of histone 3 (H3K27me3).",

author = "Noa Novershtern and Hanna, \{Jacob H.\}",

year = "2011",

month = aug,

doi = "10.1038/ncb2311",

language = "الإنجليزيّة",

volume = "13",

pages = "886--888",

journal = "Nature Cell Biology",

issn = "1465-7392",

publisher = "Nature Research",

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AU - Novershtern, Noa

AU - Hanna, Jacob H.

PY - 2011/8

Y1 - 2011/8

N2 - How the unique chromatin configuration of embryonic stem cells (ESCs) integrates inputs from exogenous stimuli to maintain pluripotency remains largely unknown. The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Stat3, a leukaemia inhibitory factor (LIF) signalling effector, by preventing repressive localized polycomb-mediated trimethylation of Lys 27 of histone 3 (H3K27me3).

AB - How the unique chromatin configuration of embryonic stem cells (ESCs) integrates inputs from exogenous stimuli to maintain pluripotency remains largely unknown. The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Stat3, a leukaemia inhibitory factor (LIF) signalling effector, by preventing repressive localized polycomb-mediated trimethylation of Lys 27 of histone 3 (H3K27me3).

UR - https://www.scopus.com/pages/publications/79961004320

U2 - 10.1038/ncb2311

DO - 10.1038/ncb2311

M3 - مقالة

SN - 1465-7392

VL - 13

SP - 886

EP - 888

JO - Nature Cell Biology

JF - Nature Cell Biology

IS - 8

ER -

EsBAF safeguards Stat3 binding to maintain pluripotency

Abstract

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