TY - JOUR
T1 - Epigenetically Heritable Alteration of Fly Development in Response to Toxic Challenge
AU - Stern, Shay
AU - Fridmann-Sirkis, Yael
AU - Braun, Erez
AU - Soen, Yoav
N1 - Funding Information: We thank E. Arama, D.S. Tawfik, M. Walker, E. Jablonka, H. Cedar, and B. Shilo for useful discussions. We thank E. Kenigsberg and A. Tanay for assistance in the bioinformatics analyses. We thank A. Orian for providing the hairy antibody, L. Gilboa for providing the UAS-HP1 RNAi and HP1 5 lines, J. Eissenberg for providing the neo R HSHP1 line, and G. Reuter for providing the hs-Su(var)3-9-EGFP line. We thank M. Galili for technical help. This work was supported by the FIRST program of the Israel Science Foundation (grant no. 1419/09), Yeda-Sela Center, and the Minerva-Weizmann Program. Y.S. was supported by CDA award from the Human Frontier Science Organization (CDA0063/2007-C) HSFPO. S.S. was supported by the Clore fellowship and the “Kahn Family Research Center on Systems Biology of the Human Cell” award.
PY - 2012/5/31
Y1 - 2012/5/31
N2 - Developing organisms have evolved a wide range of mechanisms for coping with recurrent environmental challenges. How they cope with rare or unforeseen challenges is, however, unclear as are the implications to their unchallenged offspring. Here, we investigate these questions by confronting the development of the fly, . D. . melanogaster, with artificial tissue distributions of toxic stress that are not expected to occur during fly development. We show that under a wide range of toxic scenarios, this challenge can lead to modified development that may coincide with increased tolerance to an otherwise lethal condition. Part of this response was mediated by suppression of Polycomb group genes, which in turn leads to derepression of developmental regulators and their expression in new domains. Importantly, some of the developmental alterations were epigenetically inherited by subsequent generations of unchallenged offspring. These results show that the environment can induce alternative patterns of development that are stable across multiple generations.
AB - Developing organisms have evolved a wide range of mechanisms for coping with recurrent environmental challenges. How they cope with rare or unforeseen challenges is, however, unclear as are the implications to their unchallenged offspring. Here, we investigate these questions by confronting the development of the fly, . D. . melanogaster, with artificial tissue distributions of toxic stress that are not expected to occur during fly development. We show that under a wide range of toxic scenarios, this challenge can lead to modified development that may coincide with increased tolerance to an otherwise lethal condition. Part of this response was mediated by suppression of Polycomb group genes, which in turn leads to derepression of developmental regulators and their expression in new domains. Importantly, some of the developmental alterations were epigenetically inherited by subsequent generations of unchallenged offspring. These results show that the environment can induce alternative patterns of development that are stable across multiple generations.
UR - http://www.scopus.com/inward/record.url?scp=84861662194&partnerID=8YFLogxK
U2 - 10.1016/j.celrep.2012.03.012
DO - 10.1016/j.celrep.2012.03.012
M3 - مقالة
SN - 2211-1247
VL - 1
SP - 528
EP - 542
JO - Cell Reports
JF - Cell Reports
IS - 5
ER -