Epigenetic genome-wide association methylation in aging and longevity

Danny Ben-Avraham; Radhika H. Muzumdar; Gil Atzmon

doi:https://doi.org/10.2217/epi.12.41

Epigenetic genome-wide association methylation in aging and longevity

Danny Ben-Avraham, Radhika H. Muzumdar, Gil Atzmon

Research output: Contribution to journal › Review article › peer-review

Abstract

The aging phenotype is the result of a complex interaction between genetic, epigenetic and environmental factors. Evidence suggests that epigenetic changes (i.e., a set of reversible, heritable changes in gene function or other cell phenotype that occurs without a change in DNA sequence) may affect the aging process and may be one of the central mechanisms by which aging predisposes to many age-related diseases. The total number of altered methylation sites increases with increasing age, such that they could serve as marker for chronological age. This article systematically highlights the advances made in the field of epigenomics and their contribution to the understanding of the complex physiology of aging, lifespan and age-associated diseases.

Original language	American English
Pages (from-to)	503-509
Number of pages	7
Journal	Epigenomics
Volume	4
Issue number	5
DOIs	https://doi.org/10.2217/epi.12.41
State	Published - Oct 2012
Externally published	Yes

Keywords

EWAS
aging
longevity
methylation

All Science Journal Classification (ASJC) codes

Genetics
Cancer Research

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https://doi.org/10.2217/epi.12.41

Cite this

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title = "Epigenetic genome-wide association methylation in aging and longevity",

abstract = "The aging phenotype is the result of a complex interaction between genetic, epigenetic and environmental factors. Evidence suggests that epigenetic changes (i.e., a set of reversible, heritable changes in gene function or other cell phenotype that occurs without a change in DNA sequence) may affect the aging process and may be one of the central mechanisms by which aging predisposes to many age-related diseases. The total number of altered methylation sites increases with increasing age, such that they could serve as marker for chronological age. This article systematically highlights the advances made in the field of epigenomics and their contribution to the understanding of the complex physiology of aging, lifespan and age-associated diseases.",

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AU - Ben-Avraham, Danny

AU - Muzumdar, Radhika H.

AU - Atzmon, Gil

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Y1 - 2012/10

N2 - The aging phenotype is the result of a complex interaction between genetic, epigenetic and environmental factors. Evidence suggests that epigenetic changes (i.e., a set of reversible, heritable changes in gene function or other cell phenotype that occurs without a change in DNA sequence) may affect the aging process and may be one of the central mechanisms by which aging predisposes to many age-related diseases. The total number of altered methylation sites increases with increasing age, such that they could serve as marker for chronological age. This article systematically highlights the advances made in the field of epigenomics and their contribution to the understanding of the complex physiology of aging, lifespan and age-associated diseases.

AB - The aging phenotype is the result of a complex interaction between genetic, epigenetic and environmental factors. Evidence suggests that epigenetic changes (i.e., a set of reversible, heritable changes in gene function or other cell phenotype that occurs without a change in DNA sequence) may affect the aging process and may be one of the central mechanisms by which aging predisposes to many age-related diseases. The total number of altered methylation sites increases with increasing age, such that they could serve as marker for chronological age. This article systematically highlights the advances made in the field of epigenomics and their contribution to the understanding of the complex physiology of aging, lifespan and age-associated diseases.

KW - EWAS

KW - aging

KW - longevity

KW - methylation

UR - http://www.scopus.com/inward/record.url?scp=84868557877&partnerID=8YFLogxK

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DO - https://doi.org/10.2217/epi.12.41

M3 - Review article

C2 - 23130832

SN - 1750-1911

VL - 4

SP - 503

EP - 509

JO - Epigenomics

JF - Epigenomics

IS - 5

ER -

Epigenetic genome-wide association methylation in aging and longevity

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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