TY - JOUR
T1 - Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis
AU - Miroshnikova, Yekaterina A.
AU - Cohen, Idan
AU - Ezhkova, Elena
AU - Wickström, Sara A.
N1 - Funding Information: We thank members of the Ezhkova and Wickström labs for discussions and Carmit Bar for Figure 1 illustrations. SAW is funded by the Helsinki Institute of Life Science (University of Helsinki), Wihuri Research Institute, European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement 770877 - STEMpop), Academy of Finland, Max Planck Society, Erkko Foundation, and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation; Project # 73111208 - SFB 829). EE is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number R01AR069078, and the Tisch Cancer Institute P30 Cancer Support Grant. YAM is a recipient of the EMBO Long Term Fellowship ALTF 728-2017. IC is supported by a Training Program in Stem Cell Biology fellowship from the New York State Department of Health (NYSTEM-C32561GG). Funding Information: We thank members of the Ezhkova and Wickström labs for discussions and Carmit Bar for Figure 1 illustrations. SAW is funded by the Helsinki Institute of Life Science ( University of Helsinki ), Wihuri Research Institute , European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement 770877 - STEMpop), Academy of Finland , Max Planck Society , Erkko Foundation , and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation; Project # 73111208 - SFB 829). EE is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number R01AR069078 , and the Tisch Cancer Institute P30 Cancer Support Grant. YAM is a recipient of the EMBO Long Term Fellowship ALTF 728-2017 . IC is supported by a Training Program in Stem Cell Biology fellowship from the New York State Department of Health ( NYSTEM-C32561GG ). Publisher Copyright: © 2019 The Authors
PY - 2019/4/1
Y1 - 2019/4/1
N2 - The skin epidermis is a constantly renewing stratified epithelium that provides essential protective barrier functions throughout life. Epidermal stratification is governed by a step-wise differentiation program that requires precise spatiotemporal control of gene expression. How epidermal self-renewal and differentiation are regulated remains a fundamental open question. Cell-intrinsic and cell-extrinsic mechanisms that modify chromatin structure and interactions have been identified as key regulators of epidermal differentiation and stratification. Here, we will review the recent advances in our understanding of how chromatin modifiers, tissue-specific transcription factors, and force-induced nuclear remodeling processes function to shape chromatin and to control epidermal tissue development and homeostasis.
AB - The skin epidermis is a constantly renewing stratified epithelium that provides essential protective barrier functions throughout life. Epidermal stratification is governed by a step-wise differentiation program that requires precise spatiotemporal control of gene expression. How epidermal self-renewal and differentiation are regulated remains a fundamental open question. Cell-intrinsic and cell-extrinsic mechanisms that modify chromatin structure and interactions have been identified as key regulators of epidermal differentiation and stratification. Here, we will review the recent advances in our understanding of how chromatin modifiers, tissue-specific transcription factors, and force-induced nuclear remodeling processes function to shape chromatin and to control epidermal tissue development and homeostasis.
UR - http://www.scopus.com/inward/record.url?scp=85065699767&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.gde.2019.04.014
DO - https://doi.org/10.1016/j.gde.2019.04.014
M3 - Review article
SN - 0959-437X
VL - 55
SP - 46
EP - 51
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
ER -