Entamoeba histolytica: Bridging the gap between environmental stress and epigenetic regulation

Kirschenbaum Michael; Ankri Serge

doi:10.1007/978-4-431-55200-0_11

Entamoeba histolytica: Bridging the gap between environmental stress and epigenetic regulation

Kirschenbaum Michael, Ankri Serge

Medicine

Technion - Israel Institute of Technology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Increasing evidence indicates that parasites display unique and diverse mechanisms of epigenetic regulation. In this chapter we present the current state of knowledge about the Entamoeba histolytica DNA/tRNA methyltransferase (Dnmt2) machinery and the related EhMLBP, a protein involved in the recognition of methylated DNA targets. The regulation of these epigenetic components by environmental challenges relevant to the biology of the parasite (including heat shock, glucose starvation, oxidative and nitrosative stresses) is also discussed.

Original language	English
Title of host publication	Amebiasis
Subtitle of host publication	Biology and Pathogenesis of Entamoeba
Publisher	Springer Japan
Pages	171-185
Number of pages	15
ISBN (Electronic)	9784431552000
ISBN (Print)	9784431551997
DOIs	https://doi.org/10.1007/978-4-431-55200-0_11
State	Published - 1 Jan 2015

Keywords

Dnmt2
Entamoeba
Environmental stress
Epigenetic
Protozoan parasite
Retrotransposons
tRNA methylation

All Science Journal Classification (ASJC) codes

General Immunology and Microbiology
General Medicine

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10.1007/978-4-431-55200-0_11

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AB - Increasing evidence indicates that parasites display unique and diverse mechanisms of epigenetic regulation. In this chapter we present the current state of knowledge about the Entamoeba histolytica DNA/tRNA methyltransferase (Dnmt2) machinery and the related EhMLBP, a protein involved in the recognition of methylated DNA targets. The regulation of these epigenetic components by environmental challenges relevant to the biology of the parasite (including heat shock, glucose starvation, oxidative and nitrosative stresses) is also discussed.

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Entamoeba histolytica: Bridging the gap between environmental stress and epigenetic regulation

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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