Entamoeba histolytica: Bridging the gap between environmental stress and epigenetic regulation

Kirschenbaum Michael, Ankri Serge

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Increasing evidence indicates that parasites display unique and diverse mechanisms of epigenetic regulation. In this chapter we present the current state of knowledge about the Entamoeba histolytica DNA/tRNA methyltransferase (Dnmt2) machinery and the related EhMLBP, a protein involved in the recognition of methylated DNA targets. The regulation of these epigenetic components by environmental challenges relevant to the biology of the parasite (including heat shock, glucose starvation, oxidative and nitrosative stresses) is also discussed.

Original languageEnglish
Title of host publicationAmebiasis
Subtitle of host publicationBiology and Pathogenesis of Entamoeba
PublisherSpringer Japan
Pages171-185
Number of pages15
ISBN (Electronic)9784431552000
ISBN (Print)9784431551997
DOIs
StatePublished - 1 Jan 2015

Keywords

  • Dnmt2
  • Entamoeba
  • Environmental stress
  • Epigenetic
  • Protozoan parasite
  • Retrotransposons
  • tRNA methylation

All Science Journal Classification (ASJC) codes

  • General Immunology and Microbiology
  • General Medicine

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