TY - JOUR
T1 - Entamoeba histolytica adaptation to glucose starvation
T2 - A matter of life and death
AU - Baumel-Alterzon, Sharon
AU - Ankri, Serge
N1 - Funding Information: We apologize to colleagues whose work was not cited in this review due to space constraints. This study was supported by The Israel Science Foundation (grant number 1218/10) and The German Research Foundation (grant number 784/1-2). The authors would like to acknowledge Dr. Arieh Bomzon, ConsulWrite ( www.consulwrite.com ) for his editorial assistance in preparing this review.
PY - 2014/8
Y1 - 2014/8
N2 - Parasites are often challenged by constant changes of the glucose concentration in their different hosts and/or within the different biotopes in the same host. During its life cycle, Entamoeba histolytica, the causative protozoan parasite of human amoebiasis, is exposed to both a glucose-poor environment in the colon and a glucose-rich environment in the liver. High-throughput 'omics' technologies are now widely used to characterize the cell's global response to various stresses and these technologies can survey E. histolytica's global response to fluctuations in glucose concentration in its environment. In this review, we discuss the phenotypic and metabolic responses of E. histolytica to glucose challenges, and compare these responses to those of other protozoan parasites.
AB - Parasites are often challenged by constant changes of the glucose concentration in their different hosts and/or within the different biotopes in the same host. During its life cycle, Entamoeba histolytica, the causative protozoan parasite of human amoebiasis, is exposed to both a glucose-poor environment in the colon and a glucose-rich environment in the liver. High-throughput 'omics' technologies are now widely used to characterize the cell's global response to various stresses and these technologies can survey E. histolytica's global response to fluctuations in glucose concentration in its environment. In this review, we discuss the phenotypic and metabolic responses of E. histolytica to glucose challenges, and compare these responses to those of other protozoan parasites.
UR - http://www.scopus.com/inward/record.url?scp=84904109421&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2014.06.005
DO - 10.1016/j.mib.2014.06.005
M3 - مقالة مرجعية
SN - 1369-5274
VL - 20
SP - 139
EP - 145
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -