Enhancing the gastrointestinal stability of salmon calcitonin through peptide stapling

Hiba Ghareeb, Norman Metanis

Research output: Contribution to journalArticlepeer-review

Abstract

Salmon calcitonin (sCT) is a polypeptide hormone available in the clinic. sCT is degraded in the gastrointestinal tract in minutes. In this work, a stapled analogue of salmon calcitonin, KaY-1(R24Q), was developed using the cooperative stapling between Lys and Tyr, with R24Q substitution. The analogue exhibited an improved stability in simulated gastric and intestinal fluid and retained the ability to activate the calcitonin receptor. This work will serve as a starting point for the development of an oral sCT drug.

Original languageAmerican English
Pages (from-to)6682-6685
Number of pages4
JournalChemical Communications
Volume59
Issue number44
DOIs
StatePublished - 26 Apr 2023

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • General Chemistry
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Catalysis

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