Enhancing Speckle Statistics for Imaging Inside Scattering Tissue

We exploit memory effect correlations in speckles for the imaging of incoherent fluorescent sources behind scattering tissue. These correlations are often weak when imaging thick scattering tissues and complex illumination patterns, both of which greatly limit the practicality of associated techniques. In this work, we introduce a spatial light modulator between the tissue sample and the imaging sensor and capture multiple modulations of the speckle pattern. We show that, by correctly designing the modulation patterns and the associated reconstruction algorithm, the statistical correlations in the measurements can be greatly enhanced. We exploit this to demonstrate the reconstruction of mega-pixel sized fluorescent patterns behind the scattering tissue.