@article{8fa79ee1594c46ccacc2487c989c357f,
title = "Enhancement of consolidated long-term memory by overexpression of protein kinase Mζ in the neocortex",
abstract = "Memories are more easily disrupted than improved. Many agents can impair memories during encoding and consolidation. In contrast, the armamentarium of potential memory enhancers is so far rather modest. Moreover, the effect of the latter appears to be limited to enhancing new memories during encoding and the initial period of cellular consolidation, which can last from a few minutes to hours after learning. Here, we report that overexpression in the rat neocortex of the protein kinase C isozyme protein kinase Mz (PKMz) enhances long-term memory, whereas a dominant negative PKMz disrupts memory, even long after memory has been formed.",
author = "Reut Shema and Sharon Haramati and Shiri Ron and Shoshi Hazvi and Alon Chen and Sacktor, {Todd Charlton} and Yadin Dudai",
note = "Israel-U.S. Binational Science Foundation; Nella and Leon Benoziyo Center for Neurologica Diseases; NIH [R01 MH53576, MH57068]; Israeli Academy of Sciences and HumanitiesThe support of the Israel-U.S. Binational Science Foundation (Y.D and T.C.S), the Nella and Leon Benoziyo Center for Neurologica Diseases (Y.D.), and of NIH R01 MH53576 and MH57068 (T.C.S.) is gratefully acknowledged. R.S. is supported by the Adams Fellowship program of the Israeli Academy of Sciences and Humanities. We thank R. Eilam for providing invaluable assistance in histochemistry.",
year = "2011",
month = mar,
day = "4",
doi = "10.1126/science.1200215",
language = "الإنجليزيّة",
volume = "331",
pages = "1207--1210",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6021",
}