TY - JOUR
T1 - Enhancement of consolidated long-term memory by overexpression of protein kinase Mζ in the neocortex
AU - Shema, Reut
AU - Haramati, Sharon
AU - Ron, Shiri
AU - Hazvi, Shoshi
AU - Chen, Alon
AU - Sacktor, Todd Charlton
AU - Dudai, Yadin
N1 - Israel-U.S. Binational Science Foundation; Nella and Leon Benoziyo Center for Neurologica Diseases; NIH [R01 MH53576, MH57068]; Israeli Academy of Sciences and HumanitiesThe support of the Israel-U.S. Binational Science Foundation (Y.D and T.C.S), the Nella and Leon Benoziyo Center for Neurologica Diseases (Y.D.), and of NIH R01 MH53576 and MH57068 (T.C.S.) is gratefully acknowledged. R.S. is supported by the Adams Fellowship program of the Israeli Academy of Sciences and Humanities. We thank R. Eilam for providing invaluable assistance in histochemistry.
PY - 2011/3/4
Y1 - 2011/3/4
N2 - Memories are more easily disrupted than improved. Many agents can impair memories during encoding and consolidation. In contrast, the armamentarium of potential memory enhancers is so far rather modest. Moreover, the effect of the latter appears to be limited to enhancing new memories during encoding and the initial period of cellular consolidation, which can last from a few minutes to hours after learning. Here, we report that overexpression in the rat neocortex of the protein kinase C isozyme protein kinase Mz (PKMz) enhances long-term memory, whereas a dominant negative PKMz disrupts memory, even long after memory has been formed.
AB - Memories are more easily disrupted than improved. Many agents can impair memories during encoding and consolidation. In contrast, the armamentarium of potential memory enhancers is so far rather modest. Moreover, the effect of the latter appears to be limited to enhancing new memories during encoding and the initial period of cellular consolidation, which can last from a few minutes to hours after learning. Here, we report that overexpression in the rat neocortex of the protein kinase C isozyme protein kinase Mz (PKMz) enhances long-term memory, whereas a dominant negative PKMz disrupts memory, even long after memory has been formed.
UR - https://www.scopus.com/pages/publications/79952264714
U2 - 10.1126/science.1200215
DO - 10.1126/science.1200215
M3 - Article
SN - 0036-8075
VL - 331
SP - 1207
EP - 1210
JO - Science
JF - Science
IS - 6021
ER -