Abstract
Aim: To encapsulate efavirenz (EFV) within poly(epsilon-caprolactone) (PCL) nanoparticles (NPs) and compare the oral pharmacokinetics with that of EFV-loaded micelles and pure EFV NPs. Materials & methods: EFV-loaded PCL NPs were produced by a double-emulsion/spray-drying method. Results: NPs displayed a hydrodynamic diameter of 200-250 nm. The encapsulation efficiency was 86-93% and the mass recovery was above 60%. X-ray diffraction indicated that drug and PCL underwent amorphization during the spray-drying process. Encapsulation within NPs significantly increased the maximum concentration in plasma and the bioavailability. Conclusion: EFV-loaded PCL NPs represent a promising platform to develop scalable pharmaceuticals with improved (bio)pharmaceutic performance.
| Original language | English |
|---|---|
| Pages (from-to) | 1821-1833 |
| Number of pages | 13 |
| Journal | Nanomedicine |
| Volume | 9 |
| Issue number | 12 |
| DOIs | |
| State | Published - 1 Aug 2014 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Efavirenz •
- Hiv •
- In vitro drug release •
- Oral bioavailability enhancement •
- Poly(epsilon-caprolactone) nanoparticle •
- Spray drying
All Science Journal Classification (ASJC) codes
- Bioengineering
- Medicine (miscellaneous)
- Biomedical Engineering
- General Materials Science
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