Engineering l-asparaginase for spontaneous formation of calcium phosphate bioinspired microreactors

Alexandra Louka, Irina Matlahov, Stefano Giuntini, Linda Cerofolini, Andrea Cavallo, Serena Pillozzi, Enrico Ravera, Marco Fragai, Annarosa Arcangeli, Ayyalusamy Ramamoorthy, Gil Goobes, Claudio Luchinat

Research output: Contribution to journalArticlepeer-review


Active bioinspired materials are appealing biotechnological targets, and their study is gaining momentum. These materials, which comprise of an inorganic matrix and one or more biomolecules, are extremely variable and therefore may result difficult to characterize in their intimate structure. In this work we have prepared a hydroxyapatite-l-asparaginase composite, with the perspective of using it in acute leukemia treatment. We demonstrate that the use of electron microscopy and powder X-ray diffraction, combined with the atomic-resolution information coming from solid-state NMR, allows us to understand the topology of the material and how the different components interplay to obtain an active composite.

Original languageEnglish
Pages (from-to)12719-12726
Number of pages8
JournalPhysical Chemistry Chemical Physics
Issue number18
StatePublished - 9 May 2018

All Science Journal Classification (ASJC) codes

  • General Physics and Astronomy
  • Physical and Theoretical Chemistry


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