Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants

Yael Korem Kohanim; Avichai Tendler; Avi Mayo; Nir Friedman; Uri Alon

doi:10.1016/j.immuni.2020.04.022

Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants

Yael Korem Kohanim, Avichai Tendler, Avi Mayo, Nir Friedman, Uri Alon

Research output: Contribution to journal › Article › peer-review

Abstract

Some endocrine tissues are prone to autoimmune disease, whereas others are not. Korem Kohanim et al. propose the existence of an immune surveillance mechanism wherein auto-reactive T cells remove aberrant hyperproliferating and hypersecreting endocrine cells to prevent disruption of homeostasis. Autoimmunity is the cost of this surveillance mechanism.

Original language	American English
Pages (from-to)	872-884.e5
Journal	Immunity
Volume	52
Issue number	5
DOIs	https://doi.org/10.1016/j.immuni.2020.04.022
State	Published - 19 May 2020
Externally published	Yes

Keywords

Hashimoto's thyroiditis
autoimmune disease
circuit motif
hyperparathyroidism
hypersecreting adenoma
immune surveillance
primary biliary cirrhosis
systems biology
type 1 diabetes
vitiligo

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.immuni.2020.04.022

Cite this

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abstract = "Some endocrine tissues are prone to autoimmune disease, whereas others are not. Korem Kohanim et al. propose the existence of an immune surveillance mechanism wherein auto-reactive T cells remove aberrant hyperproliferating and hypersecreting endocrine cells to prevent disruption of homeostasis. Autoimmunity is the cost of this surveillance mechanism.",

keywords = "Hashimoto's thyroiditis, autoimmune disease, circuit motif, hyperparathyroidism, hypersecreting adenoma, immune surveillance, primary biliary cirrhosis, systems biology, type 1 diabetes, vitiligo",

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AU - Tendler, Avichai

AU - Mayo, Avi

AU - Friedman, Nir

AU - Alon, Uri

PY - 2020/5/19

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KW - Hashimoto's thyroiditis

KW - autoimmune disease

KW - circuit motif

KW - hyperparathyroidism

KW - hypersecreting adenoma

KW - immune surveillance

KW - primary biliary cirrhosis

KW - systems biology

KW - type 1 diabetes

KW - vitiligo

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Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

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