Endocannabinoids: The lipid effectors of metabolic regulation in health and disease

Tony Jourdan; Pascal Degrace; Isabel González-Mariscal; Gergo Szanda; Joseph Tam

doi:https://doi.org/10.1016/B978-0-12-819404-1.00015-4

Endocannabinoids: The lipid effectors of metabolic regulation in health and disease

Tony Jourdan, Pascal Degrace, Isabel González-Mariscal, Gergo Szanda, Joseph Tam

School of Pharmacy

The Hebrew University of Jerusalem

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Endocannabinoids (eCBs) are endogenous lipid mediators that activate the cannabinoid-1 and -2 receptors (CB₁R and CB₂R, respectively), which mediate the effects of marijuana. The endocannabinoid system (ECS), consisting of eCBs, their receptors and the enzymes involved in their biosynthesis and degradation, is present in the central nervous system as well as in various peripheral tissues. The present chapter discusses accumulating evidence indicating that the ECS is involved in modulating energy homeostasis, adipose tissue metabolism, glucose and insulin balance as well as hepatic lipogenesis in health and metabolic diseases.

Original language	English
Title of host publication	Lipid Signaling and Metabolism
Publisher	Elsevier
Pages	297-320
Number of pages	24
ISBN (Electronic)	9780128194041
DOIs	https://doi.org/10.1016/B978-0-12-819404-1.00015-4
State	Published - 1 Jan 2020

Keywords

Adipocytes
CB1 receptor
CB2 receptor
Endocannabinoids
Energy homeostasis
Insulin resistance
Lipogenesis

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

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https://doi.org/10.1016/B978-0-12-819404-1.00015-4

Cite this

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abstract = "Endocannabinoids (eCBs) are endogenous lipid mediators that activate the cannabinoid-1 and -2 receptors (CB1R and CB2R, respectively), which mediate the effects of marijuana. The endocannabinoid system (ECS), consisting of eCBs, their receptors and the enzymes involved in their biosynthesis and degradation, is present in the central nervous system as well as in various peripheral tissues. The present chapter discusses accumulating evidence indicating that the ECS is involved in modulating energy homeostasis, adipose tissue metabolism, glucose and insulin balance as well as hepatic lipogenesis in health and metabolic diseases.",

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AU - Szanda, Gergo

AU - Tam, Joseph

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KW - CB1 receptor

KW - CB2 receptor

KW - Endocannabinoids

KW - Energy homeostasis

KW - Insulin resistance

KW - Lipogenesis

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Endocannabinoids: The lipid effectors of metabolic regulation in health and disease

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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