Endocannabinoids: The lipid effectors of metabolic regulation in health and disease

Tony Jourdan, Pascal Degrace, Isabel González-Mariscal, Gergo Szanda, Joseph Tam

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Endocannabinoids (eCBs) are endogenous lipid mediators that activate the cannabinoid-1 and -2 receptors (CB1R and CB2R, respectively), which mediate the effects of marijuana. The endocannabinoid system (ECS), consisting of eCBs, their receptors and the enzymes involved in their biosynthesis and degradation, is present in the central nervous system as well as in various peripheral tissues. The present chapter discusses accumulating evidence indicating that the ECS is involved in modulating energy homeostasis, adipose tissue metabolism, glucose and insulin balance as well as hepatic lipogenesis in health and metabolic diseases.

Original languageEnglish
Title of host publicationLipid Signaling and Metabolism
PublisherElsevier
Pages297-320
Number of pages24
ISBN (Electronic)9780128194041
DOIs
StatePublished - 1 Jan 2020

Keywords

  • Adipocytes
  • CB1 receptor
  • CB2 receptor
  • Endocannabinoids
  • Energy homeostasis
  • Insulin resistance
  • Lipogenesis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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