Enantioselective Crystallization on Chiral Hybrid Magnetic Polymeric Particles

Yarden Ben Moshe; Meir Abuaf; Chen Mordechai; Amos Sharoni; Yitzhak Mastai

doi:10.1021/acsomega.4c11154

Enantioselective Crystallization on Chiral Hybrid Magnetic Polymeric Particles

Yarden Ben Moshe, Meir Abuaf, Chen Mordechai, Amos Sharoni, Yitzhak Mastai

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Abstract

A new class of Janus chiral magnetic polymeric particles was fabricated for chiral resolution by enantioselective crystallization. N-Acryloyl-l/d-Phe methyl ester beads were prepared with controlled sizes and coated with ferromagnetic permalloy. Chiral discrimination by enantiopure d-Ala crystals was investigated in a model for racemic crystallization. X-ray diffraction and differential scanning calorimetry support the crystallization of the particles. Analysis of optical rotation reveals a d-Ala enantiomeric excess of about 11%, effectively establishing the concept of chiral discrimination by enantioselective crystallization on these Janus chiral magnetic polymeric particles.

Original language	English
Pages (from-to)	14075-14083
Number of pages	9
Journal	ACS Omega
Volume	10
Issue number	14
DOIs	https://doi.org/10.1021/acsomega.4c11154
State	Published - 15 Apr 2025

All Science Journal Classification (ASJC) codes

General Chemistry
General Chemical Engineering

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10.1021/acsomega.4c11154

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title = "Enantioselective Crystallization on Chiral Hybrid Magnetic Polymeric Particles",

abstract = "A new class of Janus chiral magnetic polymeric particles was fabricated for chiral resolution by enantioselective crystallization. N-Acryloyl-l/d-Phe methyl ester beads were prepared with controlled sizes and coated with ferromagnetic permalloy. Chiral discrimination by enantiopure d-Ala crystals was investigated in a model for racemic crystallization. X-ray diffraction and differential scanning calorimetry support the crystallization of the particles. Analysis of optical rotation reveals a d-Ala enantiomeric excess of about 11%, effectively establishing the concept of chiral discrimination by enantioselective crystallization on these Janus chiral magnetic polymeric particles.",

author = "Moshe, {Yarden Ben} and Meir Abuaf and Chen Mordechai and Amos Sharoni and Yitzhak Mastai",

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doi = "10.1021/acsomega.4c11154",

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AU - Moshe, Yarden Ben

AU - Abuaf, Meir

AU - Mordechai, Chen

AU - Sharoni, Amos

AU - Mastai, Yitzhak

PY - 2025/4/15

Y1 - 2025/4/15

N2 - A new class of Janus chiral magnetic polymeric particles was fabricated for chiral resolution by enantioselective crystallization. N-Acryloyl-l/d-Phe methyl ester beads were prepared with controlled sizes and coated with ferromagnetic permalloy. Chiral discrimination by enantiopure d-Ala crystals was investigated in a model for racemic crystallization. X-ray diffraction and differential scanning calorimetry support the crystallization of the particles. Analysis of optical rotation reveals a d-Ala enantiomeric excess of about 11%, effectively establishing the concept of chiral discrimination by enantioselective crystallization on these Janus chiral magnetic polymeric particles.

AB - A new class of Janus chiral magnetic polymeric particles was fabricated for chiral resolution by enantioselective crystallization. N-Acryloyl-l/d-Phe methyl ester beads were prepared with controlled sizes and coated with ferromagnetic permalloy. Chiral discrimination by enantiopure d-Ala crystals was investigated in a model for racemic crystallization. X-ray diffraction and differential scanning calorimetry support the crystallization of the particles. Analysis of optical rotation reveals a d-Ala enantiomeric excess of about 11%, effectively establishing the concept of chiral discrimination by enantioselective crystallization on these Janus chiral magnetic polymeric particles.

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JO - ACS Omega

JF - ACS Omega

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Enantioselective Crystallization on Chiral Hybrid Magnetic Polymeric Particles

Abstract

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