Emerging Roles for Eosinophils in the Tumor Microenvironment

Research output: Contribution to journalReview articlepeer-review


Eosinophils are evolutionary conserved cells largely studied in the context of allergy. Although eosinophils were first described in tumors more than 120 years ago, their roles in cancer are often overlooked. This is puzzling given their potent immune modulatory, cytotoxic, and/or tissue repair capabilities, and recent studies demonstrating key roles for eosinophils in contexts far beyond their ‘classical’ field (e.g., metabolism, thermogenesis, and tissue regeneration). Recent data suggest that this frequently ignored cell is emerging as a potent immune effector and immune modulator in the tumor microenvironment. This review discusses the relevance of eosinophils to tumorigenesis and the potential to harness their function in cancer therapies.

Original languageAmerican English
Pages (from-to)664-675
Number of pages12
Issue number11
StatePublished - 1 Nov 2016


  • cancer
  • cytotoxicity
  • eosinophils
  • eotaxin
  • inflammation
  • interleukin-5
  • tumor microenvironment

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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