Emerging implications for ribosomes in proximity to mitochondria

Bar Cohen, Adi Golani-Armon, Yoav S. Arava

Research output: Contribution to journalReview articlepeer-review


Synthesis of all proteins in eukaryotic cells, apart from a few organellar proteins, is done by cytosolic ribosomes. Many of these ribosomes are localized in the vicinity of the functional site of their encoded protein, enabling local protein synthesis. Studies in various organisms and tissues revealed that such locally translating ribosomes are also present near mitochondria. Here, we provide a brief summary of evidence for localized translation near mitochondria, then present data suggesting that these localized ribosomes may enable local translational regulatory processes in response to mitochondria needs. Finally, we describe the involvement of such localized ribosomes in the quality control of protein synthesis and mitochondria. These emerging views suggest that ribosomes localized near mitochondria are a hub for a variety of activities with diverse implications on mitochondria physiology.

Original languageEnglish
JournalSeminars in Cell and Developmental Biology
StateAccepted/In press - 2023


  • Localized translation
  • Mitochondria
  • MitoRQC
  • mRNA localization
  • Ribosomal quality control
  • Ribosomes
  • RNA binding proteins
  • Translation regulation

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology


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