Electrostatic control of bioactivity

Joshua E. Goldberger; Eric J. Berns; Ronit Bitton; Christina J. Newcomb; Samuel I. Stupp

doi:https://doi.org/10.1002/anie.201100202

Electrostatic control of bioactivity

Joshua E. Goldberger, Eric J. Berns, Ronit Bitton, Christina J. Newcomb, Samuel I. Stupp

Research output: Contribution to journal › Article › peer-review

Abstract

The power of independence: When exhibited on the surface of self-assembling peptide-amphiphile nanofibers, the hydrophobic laminin-derived IKVAV epitope induced nanofiber bundling through interdigitation with neighboring fibers and thus decreased the bioactivity of the resulting materials. The inclusion of charged amino acids in the peptide amphiphiles disrupted the tendency to bundle and led to significantly enhanced neurite outgrowth (see picture).

Original language	American English
Pages (from-to)	6292-6295
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	28
DOIs	https://doi.org/10.1002/anie.201100202
State	Published - 4 Jul 2011
Externally published	Yes

Keywords

aggregation
biological activity
nanostructures
peptides
self-assembly

All Science Journal Classification (ASJC) codes

General Chemistry
Catalysis

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https://doi.org/10.1002/anie.201100202

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title = "Electrostatic control of bioactivity",

abstract = "The power of independence: When exhibited on the surface of self-assembling peptide-amphiphile nanofibers, the hydrophobic laminin-derived IKVAV epitope induced nanofiber bundling through interdigitation with neighboring fibers and thus decreased the bioactivity of the resulting materials. The inclusion of charged amino acids in the peptide amphiphiles disrupted the tendency to bundle and led to significantly enhanced neurite outgrowth (see picture).",

keywords = "aggregation, biological activity, nanostructures, peptides, self-assembly",

author = "Goldberger, {Joshua E.} and Berns, {Eric J.} and Ronit Bitton and Newcomb, {Christina J.} and Stupp, {Samuel I.}",

year = "2011",

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doi = "https://doi.org/10.1002/anie.201100202",

language = "American English",

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AU - Goldberger, Joshua E.

AU - Berns, Eric J.

AU - Bitton, Ronit

AU - Newcomb, Christina J.

AU - Stupp, Samuel I.

PY - 2011/7/4

Y1 - 2011/7/4

N2 - The power of independence: When exhibited on the surface of self-assembling peptide-amphiphile nanofibers, the hydrophobic laminin-derived IKVAV epitope induced nanofiber bundling through interdigitation with neighboring fibers and thus decreased the bioactivity of the resulting materials. The inclusion of charged amino acids in the peptide amphiphiles disrupted the tendency to bundle and led to significantly enhanced neurite outgrowth (see picture).

AB - The power of independence: When exhibited on the surface of self-assembling peptide-amphiphile nanofibers, the hydrophobic laminin-derived IKVAV epitope induced nanofiber bundling through interdigitation with neighboring fibers and thus decreased the bioactivity of the resulting materials. The inclusion of charged amino acids in the peptide amphiphiles disrupted the tendency to bundle and led to significantly enhanced neurite outgrowth (see picture).

KW - aggregation

KW - biological activity

KW - nanostructures

KW - peptides

KW - self-assembly

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U2 - https://doi.org/10.1002/anie.201100202

DO - https://doi.org/10.1002/anie.201100202

M3 - Article

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VL - 50

SP - 6292

EP - 6295

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 28

ER -

Electrostatic control of bioactivity

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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