Electrophysiological studies in American Quarter horses with neuroaxonal dystrophy

Carrie J. Finno, Monica Aleman, Ron Ofri, Steven R. Hollingsworth, John E. Madigan, Laramie Winfield, Danika L. Bannasch

Research output: Contribution to journalArticlepeer-review


Objective: Neuroaxonal dystrophy (NAD) is a disease characterized by the sudden onset of neurologic signs in horses ranging from 4 to 36months of age. Equine degenerative myeloencephalopathy (EDM), a disease that has been associated with low vitamin E concentrations, is considered a more advanced form of NAD. The objective of this report is to describe the electrophysiological features of NAD/EDM in American Quarter horses (QHs). Horses: Six NAD/EDM-affected QHs and six unaffected QHs were evaluated by ophthalmic examination and electroretinography. Five of the NAD/EDM-affected QH and five unaffected QHs were also evaluated by electroencephalography (EEG). Results: Ophthalmic examination, ERGs, and EEGs were unremarkable in NAD/EDM cases. Conclusions: Neuroaxonal dystrophy/EDM does not appear to cause clinical signs of ocular disease or functional ERG/EEG deficits in QHs.

Original languageAmerican English
Pages (from-to)3-7
Number of pages5
JournalVeterinary Ophthalmology
Issue numberSUPPL.2
StatePublished - Sep 2012


  • Electroencephalogram
  • Electroretinogram
  • Equine degenerative myeloencephalopathy
  • Lipofuscin
  • Neuroaxonal dystrophy
  • Vitamin E

All Science Journal Classification (ASJC) codes

  • General Veterinary


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