Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals en route to tertiary alpha-fluorinated carbonyl derivatives: En route to tertiary α-fluorinated carbonyl derivatives

Jian Qiang Huang; Zackaria Nairoukh; Ilan Marek

doi:10.1039/c8ob00067k

Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals en route to tertiary alpha-fluorinated carbonyl derivatives: En route to tertiary α-fluorinated carbonyl derivatives

Jian Qiang Huang, Zackaria Nairoukh, Ilan Marek

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

A highly diastereoselective synthesis of tertiary α-fluoro carbonyl compounds is reported in only two chemical steps from a simple alkyne through the reaction of stereodefined fully substituted silyl ketene hemiaminal derivatives with Selectfluor.

Original language	English
Pages (from-to)	1079-1082
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	16
Issue number	7
DOIs	https://doi.org/10.1039/c8ob00067k
State	Published - 21 Feb 2018

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c8ob00067k

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title = "Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals en route to tertiary alpha-fluorinated carbonyl derivatives: En route to tertiary α-fluorinated carbonyl derivatives",

abstract = "A highly diastereoselective synthesis of tertiary α-fluoro carbonyl compounds is reported in only two chemical steps from a simple alkyne through the reaction of stereodefined fully substituted silyl ketene hemiaminal derivatives with Selectfluor.",

author = "Huang, {Jian Qiang} and Zackaria Nairoukh and Ilan Marek",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2018.",

year = "2018",

month = feb,

day = "21",

doi = "10.1039/c8ob00067k",

language = "الإنجليزيّة",

volume = "16",

pages = "1079--1082",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "7",

}

Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals en route to tertiary alpha-fluorinated carbonyl derivatives: En route to tertiary α-fluorinated carbonyl derivatives. / Huang, Jian Qiang; Nairoukh, Zackaria; Marek, Ilan.
In: Organic and Biomolecular Chemistry, Vol. 16, No. 7, 21.02.2018, p. 1079-1082.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals en route to tertiary alpha-fluorinated carbonyl derivatives

T2 - En route to tertiary α-fluorinated carbonyl derivatives

AU - Huang, Jian Qiang

AU - Nairoukh, Zackaria

AU - Marek, Ilan

PY - 2018/2/21

Y1 - 2018/2/21

N2 - A highly diastereoselective synthesis of tertiary α-fluoro carbonyl compounds is reported in only two chemical steps from a simple alkyne through the reaction of stereodefined fully substituted silyl ketene hemiaminal derivatives with Selectfluor.

AB - A highly diastereoselective synthesis of tertiary α-fluoro carbonyl compounds is reported in only two chemical steps from a simple alkyne through the reaction of stereodefined fully substituted silyl ketene hemiaminal derivatives with Selectfluor.

UR - http://www.scopus.com/inward/record.url?scp=85042167297&partnerID=8YFLogxK

U2 - 10.1039/c8ob00067k

DO - 10.1039/c8ob00067k

M3 - مقالة

SN - 1477-0520

VL - 16

SP - 1079

EP - 1082

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 7

ER -

Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals en route to tertiary alpha-fluorinated carbonyl derivatives: En route to tertiary α-fluorinated carbonyl derivatives

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