Electrochemically triggered release of human insulin from an insulin-impregnated reduced graphene oxide modified electrode

Florina Teodorescu; Laure Rolland; Viswanatha Ramarao; Amar Abderrahmani; Daniel Mandler; Rabah Boukherroub; Sabine Szunerits

doi:10.1039/c5cc05539c

Electrochemically triggered release of human insulin from an insulin-impregnated reduced graphene oxide modified electrode

Florina Teodorescu, Laure Rolland, Viswanatha Ramarao, Amar Abderrahmani, Daniel Mandler, Rabah Boukherroub, Sabine Szunerits

Institute of Chemistry

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

An electrochemical insulin-delivery system based on reduced graphene oxide impregnated with insulin is described. Upon application of a potential pulse of -0.8 V for 30 min, up to 70 ± 4% of human insulin was released into a physiological medium while preserving its biological activity.

Original language	English
Pages (from-to)	14167-14170
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	75
DOIs	https://doi.org/10.1039/c5cc05539c
State	Published - 30 Jul 2015

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c5cc05539c

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title = "Electrochemically triggered release of human insulin from an insulin-impregnated reduced graphene oxide modified electrode",

abstract = "An electrochemical insulin-delivery system based on reduced graphene oxide impregnated with insulin is described. Upon application of a potential pulse of -0.8 V for 30 min, up to 70 ± 4\% of human insulin was released into a physiological medium while preserving its biological activity.",

author = "Florina Teodorescu and Laure Rolland and Viswanatha Ramarao and Amar Abderrahmani and Daniel Mandler and Rabah Boukherroub and Sabine Szunerits",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

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T1 - Electrochemically triggered release of human insulin from an insulin-impregnated reduced graphene oxide modified electrode

AU - Teodorescu, Florina

AU - Rolland, Laure

AU - Ramarao, Viswanatha

AU - Abderrahmani, Amar

AU - Mandler, Daniel

AU - Boukherroub, Rabah

AU - Szunerits, Sabine

PY - 2015/7/30

Y1 - 2015/7/30

N2 - An electrochemical insulin-delivery system based on reduced graphene oxide impregnated with insulin is described. Upon application of a potential pulse of -0.8 V for 30 min, up to 70 ± 4% of human insulin was released into a physiological medium while preserving its biological activity.

AB - An electrochemical insulin-delivery system based on reduced graphene oxide impregnated with insulin is described. Upon application of a potential pulse of -0.8 V for 30 min, up to 70 ± 4% of human insulin was released into a physiological medium while preserving its biological activity.

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U2 - 10.1039/c5cc05539c

DO - 10.1039/c5cc05539c

M3 - مقالة

C2 - 26257079

SN - 1359-7345

VL - 51

SP - 14167

EP - 14170

JO - Chemical Communications

JF - Chemical Communications

IS - 75

ER -

Electrochemically triggered release of human insulin from an insulin-impregnated reduced graphene oxide modified electrode

Abstract

All Science Journal Classification (ASJC) codes

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