TY - JOUR
T1 - Effects of initiating moderate wine intake on abdominal adipose tissue in adults with type 2 diabetes
T2 - A 2-year randomized controlled trial
AU - Golan, Rachel
AU - Shelef, Ilan
AU - Shemesh, Elad
AU - Henkin, Yaakov
AU - Schwarzfuchs, Dan
AU - Gepner, Yftach
AU - Harman-Boehm, Ilana
AU - Witkow, Shula
AU - Friger, Michael
AU - Chassidim, Yoash
AU - Liberty, Idit F.
AU - Sarusi, Benjamin
AU - Serfaty, Dana
AU - Bril, Nitzan
AU - Rein, Michal
AU - Cohen, Noa
AU - Ben-Avraham, Sivan
AU - Ceglarek, Uta
AU - Stumvoll, Michael
AU - Blüher, Matthias
AU - Thiery, Joachim
AU - Stampfer, Meir J.
AU - Rudich, Assaf
AU - Shai, Iris
N1 - Funding Information: Financial support: This work was supported by the European Foundation for the Study of Diabetes. The European Foundation for the Study of Diabetes had no role in the design, analysis or writing of this article. Publisher Copyright: © The Authors 2016.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Objective To generate evidence-based conclusions about the effect of wine consumption on weight gain and abdominal fat accumulation and distribution in patients with type 2 diabetes. Design In the 2-year randomized controlled CASCADE (CArdiovaSCulAr Diabetes & Ethanol) trial, patients following a Mediterranean diet were randomly assigned to drink 150 ml of mineral water, white wine or red wine with dinner for 2 years. Visceral adiposity and abdominal fat distribution were measured in a subgroup of sixty-five participants, using abdominal MRI. Setting Ben-Gurion University of the Negev, Soroka-Medical Center and the Nuclear Research Center Negev, Israel. Subjects Alcohol-abstaining adults with well-controlled type 2 diabetes. Results Forty-eight participants (red wine, n 27; mineral water, n 21) who completed a second MRI measurement were included in the 2-year analysis. Similar weight losses (sd) were observed: red wine 1·3 (3·9) kg; water 1·0 (4·2) kg (P=0·8 between groups). Changes (95 % CI) in abdominal adipose-tissue distribution were similar: red wine, visceral adipose tissue (VAT) -3·0 (-8·0, 2·0) %, deep subcutaneous adipose tissue (DSAT) +5·2 (-1·1, 11·6) %, superficial subcutaneous adipose tissue (SSAT) -1·9 (-5·0, 1·2) %; water, VAT -3·2 (-8·9, 2·5) %, DSAT +2·9 (-2·8, 8·6) %, SSAT -0·15 (-3·3, 2·9) %. No changes in antidiabetic medication and no substantial changes in energy intake (+126 (sd 2889) kJ/d (+30·2 (sd 690) kcal/d), P=0·8) were recorded. A 2-year decrease in glycated Hb (β=0·28, P=0·05) was associated with a decrease in VAT. Conclusions Moderate wine consumption, as part of a Mediterranean diet, in persons with controlled diabetes did not promote weight gain or abdominal adiposity.
AB - Objective To generate evidence-based conclusions about the effect of wine consumption on weight gain and abdominal fat accumulation and distribution in patients with type 2 diabetes. Design In the 2-year randomized controlled CASCADE (CArdiovaSCulAr Diabetes & Ethanol) trial, patients following a Mediterranean diet were randomly assigned to drink 150 ml of mineral water, white wine or red wine with dinner for 2 years. Visceral adiposity and abdominal fat distribution were measured in a subgroup of sixty-five participants, using abdominal MRI. Setting Ben-Gurion University of the Negev, Soroka-Medical Center and the Nuclear Research Center Negev, Israel. Subjects Alcohol-abstaining adults with well-controlled type 2 diabetes. Results Forty-eight participants (red wine, n 27; mineral water, n 21) who completed a second MRI measurement were included in the 2-year analysis. Similar weight losses (sd) were observed: red wine 1·3 (3·9) kg; water 1·0 (4·2) kg (P=0·8 between groups). Changes (95 % CI) in abdominal adipose-tissue distribution were similar: red wine, visceral adipose tissue (VAT) -3·0 (-8·0, 2·0) %, deep subcutaneous adipose tissue (DSAT) +5·2 (-1·1, 11·6) %, superficial subcutaneous adipose tissue (SSAT) -1·9 (-5·0, 1·2) %; water, VAT -3·2 (-8·9, 2·5) %, DSAT +2·9 (-2·8, 8·6) %, SSAT -0·15 (-3·3, 2·9) %. No changes in antidiabetic medication and no substantial changes in energy intake (+126 (sd 2889) kJ/d (+30·2 (sd 690) kcal/d), P=0·8) were recorded. A 2-year decrease in glycated Hb (β=0·28, P=0·05) was associated with a decrease in VAT. Conclusions Moderate wine consumption, as part of a Mediterranean diet, in persons with controlled diabetes did not promote weight gain or abdominal adiposity.
KW - Abdominal adipose tissue
KW - MRI
KW - Mediterranean diet
KW - Type 2 diabetes
KW - Wine
UR - http://www.scopus.com/inward/record.url?scp=84989856968&partnerID=8YFLogxK
U2 - https://doi.org/10.1017/S1368980016002597
DO - https://doi.org/10.1017/S1368980016002597
M3 - Article
SN - 1368-9800
VL - 20
SP - 549
EP - 555
JO - Public Health Nutrition
JF - Public Health Nutrition
IS - 3
ER -
